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Table 1 GC-related terminologies

From: An adaptive detection method for fetal chromosomal aneuploidy using cell-free DNA from 447 Korean women

Terminologies Definition
GC content The percentage of guanine and cytosine nitrogenous bases
GC content of a sample The GC content of all unique reads of each chromosome of a sample, which are mapped to the corresponding chromosome of the reference genome
GC range The range of GC content of a sample
Unit value of GC content A unit value used to increase or decrease the range of GC content of each chromosome of a sample (default = 0.001)
The GC value of a test sample The GC content of all unique reads of each chromosome of a test sample
Reads fraction of a sample The percentage of all unique reads of each chromosome of a sample, which are mapped to each corresponding chromosome of reference genome
Unit value of reads fraction A unit value used to increase or decrease the range of reads fraction of each chromosome of a sample (default = 0.00005)
The RF value of a test sample The reads fraction value of all unique reads of each chromosome of a test sample, which was determined by fitting predicted fraction of reads calculated as \( R{f}_{i^{\prime }{j}^{\prime}}^{\hbox{'}} = \upalpha +\upbeta \times G{C}_{i^{\prime }{j}^{\prime }} \) from all reference samples