Adaptation of a RAS pathway activation signature from FF to FFPE tissues in colorectal cancer

BMC Medical Genomics

Table 3 Performance of the 16-gene PAM classifier on the 54 samples

Validation dataset	Class	Sensitivity^a	Specificity^b	LOOCV error rate
Affy FF	Mut	0.852 = 23/27	0.778 = 21/27	19 %
NanoS_FFPE	Mut	0.704 = 19/27	0.741 = 20/27	28 %
Affy_FFPE	Mut	0.519 = 14/27	0.889 = 24/27	30 %

Note: Samples were classified as either KRAS/BRAF mutant (Mut, n = 27) or KRAS/BRAF wild-type (WT, n = 27). Class prediction was performed using the Affy_FF, Affy_FFPE and NanoS_FFPE samples sets
^a = number of predicted mutants divided by number of true mutants
^b = number of predicted WT divided by number of true WT

ISSN: 1755-8794