Table 2 Genes implicated in the top canonical pathways (HUGO gene symbols)
Pathway | Binning Method | Scaling Method |
|---|---|---|
Agranulocyte Adhesion and Diapedesis | ICAM2,PF4, MYH1, CLDN4, HRH1, MYH10, CCL1, CLDN1, IL37, CCL19, ITGA1, IL1A, AOC3, MYH8, CCL17, IL36G, MMP1, MYH13, MMP16 | ICAM2, PF4, MYH1, MYH2, CLDN4, CCL1, CLDN1, IL37, CCL19, ITGA1, MYH8, IL36G, MYH13, IL33, MMP16 |
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | OAS1, IL3, NOD1, OAS2, DDX58, NFKB2, IL11, TLR3, IFNA1/IFNA13, OAS3, IL1A, IL5, CNTF, PRKD1 | MBL2, OAS1, IL2, IL3, IL11, TLR3, IFNA1/IFNA13, OAS3, OAS2, IL12B, DDX58, PRKD1 |
Role of Cytokines in Mediating Communication between Immune Cells | IL3, IL15, IFNA1/IFNA13, IL1A, IL5, IL36G, IL37 | IL2, IL3, IL15, IFNA1/IFNA13, IL12B, IL36G, IFNA2, IL33, IL37 |
Role of Hypercytokinemia/Hyperchemokinemia in the Pathogenesis of Influenza | IL15, CCR1, IFNA1/IFNA13, IL1A, IL36G, IL37 | IL15, CCR1, IFNA1/IFNA13, IL12B, IL36G, IFNA2, IL33, IL37 |
Interferon Signaling | OAS1, IRF9, IFIT1, IFNA1/IFNA13, IFIT3, IFITM2, MX1 | OAS1, IFIT1, IFNA1/IFNA13, IFIT3, IFITM2, MX1 |
Oxidative Phosphorylation | CYCS, UQCR11, NDUFS1, COX6B1, ATP5G2, NDUFA9, NDUFA7, COX6A1, NDUFS5, ATP5H, NDUFB1, ATP5C1, ATPAF2 | COX6B1, NDUFA7, COX6A1, ATPAF2, NDUFS1 |
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis | IRAK1, IL15, WNT7B, CHP1, SFRP1, DKK1, TRADD, FZD7, IL37, FZD5, IRAK4, WNT2B, PRSS1, TLR3, CCND1, IL1A, PRKD1, WIF1, IL36G, MMP1, FCGR3A/FCGR3B | IL15, TNFSF11, WNT7B, CHP1, DKK2, SFRP1, DKK1, TRADD, FZD7, IL37, FZD5, IRAK4, PRSS1, TLR3, CCND1, PRKD1, WIF1, IL36G, IL33, FCGR3A/FCGR3B |
Toll-like Receptor Signaling | NFKB2, IRAK1, TNFAIP3, TLR3, IL1A, TAB2, IL36G, IL37, IRAK4 | TNFAIP3, TLR3, IL12B, IL36G, IL33, IL37, IRAK4 |