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Table 2 Genes implicated in the top canonical pathways (HUGO gene symbols)

From: A meta-analysis of public microarray data identifies gene regulatory pathways deregulated in peripheral blood mononuclear cells from individuals with Systemic Lupus Erythematosus compared to those without

Pathway Binning Method Scaling Method
Agranulocyte Adhesion and Diapedesis ICAM2,PF4, MYH1, CLDN4, HRH1, MYH10, CCL1, CLDN1, IL37, CCL19, ITGA1, IL1A, AOC3, MYH8, CCL17, IL36G, MMP1, MYH13, MMP16 ICAM2, PF4, MYH1, MYH2, CLDN4, CCL1, CLDN1, IL37, CCL19, ITGA1, MYH8, IL36G, MYH13, IL33, MMP16
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses OAS1, IL3, NOD1, OAS2, DDX58, NFKB2, IL11, TLR3, IFNA1/IFNA13, OAS3, IL1A, IL5, CNTF, PRKD1 MBL2, OAS1, IL2, IL3, IL11, TLR3, IFNA1/IFNA13, OAS3, OAS2, IL12B, DDX58, PRKD1
Role of Cytokines in Mediating Communication between Immune Cells IL3, IL15, IFNA1/IFNA13, IL1A, IL5, IL36G, IL37 IL2, IL3, IL15, IFNA1/IFNA13, IL12B, IL36G, IFNA2, IL33, IL37
Role of Hypercytokinemia/Hyperchemokinemia in the Pathogenesis of Influenza IL15, CCR1, IFNA1/IFNA13, IL1A, IL36G, IL37 IL15, CCR1, IFNA1/IFNA13, IL12B, IL36G, IFNA2, IL33, IL37
Interferon Signaling OAS1, IRF9, IFIT1, IFNA1/IFNA13, IFIT3, IFITM2, MX1 OAS1, IFIT1, IFNA1/IFNA13, IFIT3, IFITM2, MX1
Oxidative Phosphorylation CYCS, UQCR11, NDUFS1, COX6B1, ATP5G2, NDUFA9, NDUFA7, COX6A1, NDUFS5, ATP5H, NDUFB1, ATP5C1, ATPAF2 COX6B1, NDUFA7, COX6A1, ATPAF2, NDUFS1
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis IRAK1, IL15, WNT7B, CHP1, SFRP1, DKK1, TRADD, FZD7, IL37, FZD5, IRAK4, WNT2B, PRSS1, TLR3, CCND1, IL1A, PRKD1, WIF1, IL36G, MMP1, FCGR3A/FCGR3B IL15, TNFSF11, WNT7B, CHP1, DKK2, SFRP1, DKK1, TRADD, FZD7, IL37, FZD5, IRAK4, PRSS1, TLR3, CCND1, PRKD1, WIF1, IL36G, IL33, FCGR3A/FCGR3B
Toll-like Receptor Signaling NFKB2, IRAK1, TNFAIP3, TLR3, IL1A, TAB2, IL36G, IL37, IRAK4 TNFAIP3, TLR3, IL12B, IL36G, IL33, IL37, IRAK4