DNA methylation patterns associated with oxidative stress in an ageing population

BMC Medical Genomics

Table 2 Association of oxidative marker-associated CpGs with incident T2D^a events (permutation p-value < 0.01)

					Primary model			Secondary model^d
Disease outcome	CpG	Gene	Description	Gene Property	OR (95% CIs)^b	Nominal P-value	Permutation P-value^c	P-value	Oxidative marker association (Direction)^e
T2D	cg08170869	HIST1H4D	Histone cluster 1, H4d	3'-UTR	1.39 (1.15–1.57)	3.39E-03	4.40E-03	9.19E-03	GSH (+)
T2D	cg03465880	DVL1	Dishevelled segment polarity protein 1	Body	1.31 (1.10–1.47)	7.27E-03	8.00E-03	6.48E-03	GSH (−)

T2D type 2 diabetes, CpG cytosine-guanine site, OR odds ratio, CI confidence intervals, GSH reduced glutathione, SD standard deviation
^aEvents up to 10 years after baseline; number of T2D events = 71
^bCorresponds to the OR increase in risk of disease per SD decrement in DNA methylation
^cP-value from permutation test (n = 10,000 permutations)
^dSecondary model also included BMI and smoking
^eDirection of association between oxidative marker(s) and methylation at CpG site. A + symbol corresponds to that increased levels of DNA methylation associate with increased levels of the oxidative marker

ISSN: 1755-8794