| | | | |
Primary model
|
Secondary modeld
| |
---|
Disease outcome
|
CpG
|
Gene
|
Description
|
Gene Property
|
OR (95% CIs)b
|
Nominal P-value
|
Permutation P-valuec
|
P-value
|
Oxidative marker association (Direction)e
|
---|
T2D
|
cg08170869
|
HIST1H4D
|
Histone cluster 1, H4d
|
3'-UTR
|
1.39 (1.15–1.57)
|
3.39E-03
|
4.40E-03
|
9.19E-03
|
GSH (+)
|
T2D
|
cg03465880
|
DVL1
|
Dishevelled segment polarity protein 1
|
Body
|
1.31 (1.10–1.47)
|
7.27E-03
|
8.00E-03
|
6.48E-03
|
GSH (−)
|
- T2D type 2 diabetes, CpG cytosine-guanine site, OR odds ratio, CI confidence intervals, GSH reduced glutathione, SD standard deviation
- aEvents up to 10 years after baseline; number of T2D events = 71
- bCorresponds to the OR increase in risk of disease per SD decrement in DNA methylation
- cP-value from permutation test (n = 10,000 permutations)
- dSecondary model also included BMI and smoking
- eDirection of association between oxidative marker(s) and methylation at CpG site. A + symbol corresponds to that increased levels of DNA methylation associate with increased levels of the oxidative marker