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Fig. 5 | BMC Medical Genomics

Fig. 5

From: CLImAT-HET: detecting subclonal copy number alterations and loss of heterozygosity in heterogeneous tumor samples from whole-genome sequencing data

Fig. 5

The accuracy of inferred copy numbers of different methods on simulated samples. The abilities of CLImAT-HET, OncoSNP-SEQ and CLImAT in inferring tumor genotypes are assessed in simulated dataset. A segment is considered to be accurately identified only if both the total and major copy numbers of the segment are accurately identified. For each simulated sample, the total and major copy number profiles of all segments predefined in simulation experiment are used as the golden standard for evaluation. The performance of different methods on homogeneous samples (a), tumor samples with two clonal populations (b) and three clonal populations (c) is assessed respectively, the x-axis represents the sample Id as defined in Additional file 3

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BMC Medical Genomics

ISSN: 1755-8794

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