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Fig. 1 | BMC Medical Genomics

Fig. 1

From: N-of-1-pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes

Fig. 1

The outline of MixEnrich. Single-subject paired transcriptomes (e.g., healthy and tumor, left panel) are used as the input for the clustering procedure (middle panel). The mixture model clusters all mRNAs of the subject into two groups, determining dysregulated mRNAs. The dysregulated mRNAs are then tested for enrichment into pathways using a Fisher’s Exact Test. FC = fold change; |log2FC| = the absolute value of log2 transformed fold-change; DEG = differentially expressed mRNAs; FET = Fisher’s Exact Test

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