Table 2 Gene-based association results (p-values) of rare variants (MAF < 5%; SNPs and Indels) of genes near the APOE region with CSF biomarker Aβ1-42 with and without adjusting for APOE genotypes
Gene | SNP + Indel | SNP | ||
|---|---|---|---|---|
p-value | p-value adjusted for APOE genotype | p-value | p-value adjusted for APOE genotype | |
BCL3 | 8.38E-04 | 0.0056 | 7.60E-04 | 0.0054 |
CBLC | 7.07E-05 | 0.0011 | 7.35E-05 | 0.0013 |
BCAM | 1.97E-04 | 0.0005 | 2.49E-04 | 0.0006 |
PVRL2 | 3.55E-05 | 0.3842 | 4.40E-05 | 0.4605 |
TOMM40 | 6.84E-07 | 0.0922 | 5.01E-07 | 0.0880 |
APOE | 3.35E-10 | 0.0039 | 4.08E-07 | 0.0036 |
APOC1 | 6.18E-11 | 0.2394 | 2.85E-11 | 0.1636 |
APOC1P1 | 4.43E-02 | 0.0145 | 6.16E-02 | 0.0097 |
APOC4 | 2.11E-02 | 0.2062 | 1.60E-02 | 0.1642 |
APOC2 | 2.23E-01 | 0.5363 | 1.64E-01 | 0.5102 |
CLPTM1 | 1.02E-02 | 0.0438 | 9.12E-03 | 0.0377 |
RELB | 2.36E-04 | 0.0053 | 1.51E-04 | 0.0042 |