|IGNITE Site||Principal Investigators||Study Name||Study Goals|
|Duke University School of Medicine||Geoffery Ginsburg, MD, PhD and Lori A. Orlando, MD, MHS||
Implementation, Adoption, and Utility of Family History|
in Diverse Care Settings
• Develop an optimal strategy for implementing a patient-facing web-based family health history tool, MeTree, into routine clinical practice in diverse settings.|
• Demonstrate the effectiveness of MeTree in increasing uptake of risk stratified evidence-based prevention guidelines.
• Create a standardized family health history storage database that can integrate with electronic medical records for bi-directional communication of family and personal history data and risk assessment results.
|Indiana University School of Medicine||Paul Dexter, MD and Todd Skaar, PhD||
INGENIOUS: Indiana GENomics Implementation,|
an Opportunity for the Under-Served
• Test the hypothesis that a CLIA certified genotyping targeted at 24 widely used drugs is associated with significant reductions in hospital and outpatient economic costs incurred over 1 year.|
• Test whether pharmacogenetic testing is associated with significant improvements in clinical outcomes over 1 year.
|Icahn School of Medicine at Mount Sinai||Carol R. Horowitz, MD, MPH||The GUARDD Study: Genetic testing to Understand and Address Renal Disease Disparities||• Conduct a randomized trial in a network of community health centers and primary care facilities to study processes, effects and challenges of incorporating information for apolipoprotein L1 (APOL1)-attributable genetic risk for end stage kidney disease in patients of African ancestry with hypertension.|
|University of Florida College of Pharmacy||Julie A. Johnson, PharmD||Genomic Medicine Implementation: The Personalized Medicine Program (PMP)||
• Partner with health professionals and patients at UF Health and across the state to develop, implement, study and refine methods that allow genetic information to be used as a routine part of patient care.|
• Engage in expansion to Private and Community-based Practices in Florida.
• Develop programs in Genomic Medicine Education.
|University of Maryland School of Medicine||Toni I. Pollin, MS, PhD||Genomic Diagnosis and Individualized Therapy of Highly Penetrant Genetic Diabetes||• Implement and evaluate a Personalized Diabetes Medicine Program (PDMP) in four diverse health care settings to enhance the identification and opportunities for individualized therapy of individuals and family members affected by highly penetrant/ monogenic diabetes.|
|Vanderbilt University Medical Center||Joshua C. Denny, MD, MS and Mia Levy, MD, PhD||Integrated, Individualized, and Intelligent Prescribing (I3P) Network||
• Develop, maintain, and disseminate genome-informed clinical decision support within Adopter Sites.|
• Select and prospectively genotype patients within Adopter Sites for subsequent genotype-tailored therapy.
• Evaluate the impact of integrating genetic data and clinical decision support into Adopter Site EMRs.