Table 1 IGNITE (Implementing GeNomics In pracTicE) projects

Duke University School of Medicine

Geoffery Ginsburg, MD, PhD and Lori A. Orlando, MD, MHS

Implementation, Adoption, and Utility of Family History

in Diverse Care Settings

• Develop an optimal strategy for implementing a patient-facing web-based family health history tool, MeTree, into routine clinical practice in diverse settings.

• Demonstrate the effectiveness of MeTree in increasing uptake of risk stratified evidence-based prevention guidelines.

• Create a standardized family health history storage database that can integrate with electronic medical records for bi-directional communication of family and personal history data and risk assessment results.

Indiana University School of Medicine

Paul Dexter, MD and Todd Skaar, PhD

INGENIOUS: Indiana GENomics Implementation,

an Opportunity for the Under-Served

• Test the hypothesis that a CLIA certified genotyping targeted at 24 widely used drugs is associated with significant reductions in hospital and outpatient economic costs incurred over 1 year.

• Test whether pharmacogenetic testing is associated with significant improvements in clinical outcomes over 1 year.

Icahn School of Medicine at Mount Sinai

Carol R. Horowitz, MD, MPH

The GUARDD Study: Genetic testing to Understand and Address Renal Disease Disparities

• Conduct a randomized trial in a network of community health centers and primary care facilities to study processes, effects and challenges of incorporating information for apolipoprotein L1 (APOL1)-attributable genetic risk for end stage kidney disease in patients of African ancestry with hypertension.

University of Florida College of Pharmacy

Julie A. Johnson, PharmD

Genomic Medicine Implementation: The Personalized Medicine Program (PMP)

• Partner with health professionals and patients at UF Health and across the state to develop, implement, study and refine methods that allow genetic information to be used as a routine part of patient care.

• Engage in expansion to Private and Community-based Practices in Florida.

• Develop programs in Genomic Medicine Education.

University of Maryland School of Medicine

Toni I. Pollin, MS, PhD

Genomic Diagnosis and Individualized Therapy of Highly Penetrant Genetic Diabetes

• Implement and evaluate a Personalized Diabetes Medicine Program (PDMP) in four diverse health care settings to enhance the identification and opportunities for individualized therapy of individuals and family members affected by highly penetrant/ monogenic diabetes.

Vanderbilt University Medical Center

Joshua C. Denny, MD, MS and Mia Levy, MD, PhD

Integrated, Individualized, and Intelligent Prescribing (I³P) Network

• Develop, maintain, and disseminate genome-informed clinical decision support within Adopter Sites.

• Select and prospectively genotype patients within Adopter Sites for subsequent genotype-tailored therapy.

• Evaluate the impact of integrating genetic data and clinical decision support into Adopter Site EMRs.