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Table 1 Pharmacogenetic tests provided by 23andMe

From: Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe

Drugs Gene Variant SNP Purpose of test FDA/PharmGKB Guidancea Guidelinesb
Abacavir HLA-B *57:01 rs2395029 Hypersensitivity reactions Genetic testing required CPIC, DPWG CPIC, DPWG
Acetaldehyde ALDH2 *2 rs671 Toxicity and risk of oesophageal squamous cell carcinoma No recommendation -
Clopidogrel (Plavix®) CYP2C19 *2 rs4244285 Efficacy and ADRs Genetic testing recommendation CPIC, DPWG
   *3 rs4986893    
   *4 rs28399504    
   *8 rs41291556    
   *17 rs12248560    
Fluorouracil (Adrucil®) DPYD *2A rs3918290 Toxicity and ADRs Actionable PGx CPIC, DPWG
Peginterferon alpha (PEG-IFN-alpha) & ribavirin (RBV) 19q13 region   rs8099917 Hepatitis C treatment failure Actionable PGx CPIC
Phenytoin CYP2C9 *2 rs1799853 Sensitivity and Dosage adjustment Actionable PGx CPIC, DPWG
   *3 rs1057910    
Proton Pump Inhibitor (PPI) CYP2C19 *2 rs4244285 Efficacy and Dosage adjustment Informative PGx DPWG
   *3 rs4986893    
   *4 rs28399504    
   *8 rs41291556    
   *17 rs12248560    
Pseudocholinesterase BCHE F1 rs28933389 ADR - extended paralysis and apnoea Actionable PGx -
Deficiency   F2 rs28933390    
   A rs1799807    
Simvastatin SLCO1B1 *5 rs4149056 ADR - Myopathy No recommendation CPIC
Sulfonylurea CYP2C9 *2 rs1799853 Efficacy and Dosage adjustment No recommendation DPWG
   *3 rs1057910    
Thiopurine Methyltransferase TPMT c.460G > A, *3B rs1800460 Toxicity and ADRs Genetic testing recommended CPIC, DPWG
   c.238G > C, *2 rs1800462    
   c.719A > G, *3C rs1142345    
Warfarin CYP2C9 *2 rs1799853 Efficacy and Dosage adjustment Actionable PGx CPIC
   *3 rs1057910    
  VKORC1   rs9923231    
  1. aPharmGKB evaluated the pharmacogenetic (PGx) information provided by U.S. FDA approved drug labels, and assigned each test with a level of recommendation according to the level of clinical evidence, [7] The levels begin from genetic testing required, genetic test recommended, Actionable PGx to Informative PGx.
  2. b: Guidelines from https://www.pharmgkb.org/view/dosing-guidelines.do published by the Clinical Pharmacogenetics Implementation Consortium (CPIC) or the Royal Dutch Association for the Advancement of Pharmacy - Pharmacogenetics Working Group (DPWG)
  3. *used to indicate that these values represent a given variant in the literature