Fig. 15

Detection of transcription factor binding sites (TFBS) in proximity to gene-desert regions involved in chimera formation. (a) A search was carried out for documented transcription factor binding sites (TFBS; grey box) within 8 kb from gene-desert transcripts (black box) involved in breast cancer gene fusions. (b) At least one active TFBS is located within 8 KB of gene-desert transcripts involved in gene-fusions in cancer. The distribution of the locations of TFBS from the gene-desert transcripts (red line) is identical to that associated with annotated reference transcripts (blue line). The x-axis is the distance in kilobases of a TFBS detected from a transcript; the y-axis is the percentage of transcripts with a specific TFBS distance corresponding to X-axis