Fig. 5

Simulations were used to predict the power to detect each true somatic variant assuming the sample fraction and copy number were correctly called. For each clone and each sample, the true positive rate is plotted against the power predicted from the simulations. The size of the bubble is proportional to the number of true positive variants in each clone, the color the points represents the sample fraction of the clone, and the number indicates the sample number. As expected, the highest sample fraction clone has the worse predicted and observed sensitivity. The graph on the left includes all of the true somatic variants, and the graph on the right only includes those that pass the quality filters. We can see that the predicted power correlates well with the measured sensitivity, particularly when the low quality variants are excluded