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Table 2 Genes significantly associated with ritodrine-induced side effects

From: Deleterious genetic variants in ciliopathy genes increase risk of ritodrine-induced cardiac and pulmonary side effects

Gene symbol Gene name FDR P G (mean ± SD) Gene functional category
Case, (n = 13) Control, (n = 30) ION ATP Ca2+ CP PK
AASDH Aminoadipate-Semialdehyde Dehydrogenase 0.019104 0.000041 0.16 ± 0.19 0.58 ± 0.44     
ARMC9 Armadillo Repeat Containing 9 0.025396 0.000057 0.06 ± 0.03 0.44 ± 0.46      
B9D2 B9 Protein Domain 2 0.012597 0.000017 0.25 ± 0.33 0.82 ± 0.36      
BLK B lymphoid tyrosine kinase 0.007009 0.000004 0.16 ± 0.00 0.58 ± 0.43      
CARS2 Cysteinyl-TRNA Synthetase 2, Mitochondrial (Putative) 0.068711 0.000227 0.23 ± 0.35 0.73 ± 0.43    
CD1A CD1a Molecule 0.061968 0.000192 0.35 ± 0.37 0.86 ± 0.33      
CSPG5 Chondroitin Sulfate Proteoglycan 5 (Neuroglycan C) 0.075577 0.000336 0.24 ± 0.00 0.49 ± 0.36      
CYP1A1 Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 0.065067 0.000209 0.03 ± 0.03 0.36 ± 0.46    
CYP8B1 Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 0.012973 0.000020 0.45 ± 0.09 0.71 ± 0.26    
FAT4 FAT Atypical Cadherin 4 0.092483 0.000539 0.23 ± 0.10 0.43 ± 0.28     
FUT6 Fucosyltransferase 6 (Alpha (1,3) Fucosyltransferase) 0.051144 0.000147 0.14 ± 0.04 0.46 ± 0.42      
GALNT10 Polypeptide N-Acetylgalactosaminyltransferase 10 0.092483 0.000549 0.35 ± 0.21 0.66 ± 0.35     
HHATL Hedgehog Acyltransferase-Like 0.076828 0.000369 0.27 ± 0.11 0.50 ± 0.30      
IFT74 Intraflagellar Transport 74 0.011408 0.000014 0.25 ± 0.10 0.56 ± 0.32      
ICE1 Interactor Of Little Elongation Complex ELL Subunit 1 0.014088 0.000026 0.49 ± 0.08 0.70 ± 0.23      
KNDC1 Kinase Non-Catalytic C-Lobe Domain (KIND) Containing 1 0.099453 0.000617 0.34 ± 0.03 0.53 ± 0.29      
NKAIN3 Na+/K+ Transporting ATPase Interacting 3 0.014088 0.000026 0.21 ± 0.08 0.56 ± 0.40      
OR6B1 Olfactory Receptor, Family 6, Subfamily B, Member 1 0.092483 0.000562 0.28 ± 0.02 0.50 ± 0.33      
PSMD9 Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 9 0.092483 0.000511 0.43 ± 0.40 0.91 ± 0.25      
PXT1 Peroxisomal, Testis Specific 1 0.075577 0.000336 0.02 ± 0.00 0.35 ± 0.47      
RBBP8NL RBBP8 N-Terminal Like 0.092483 0.000564 0.21 ± 0.25 0.58 ± 0.43      
RSPH3 Radial Spoke 3 Homolog (Chlamydomonas) 0.012770 0.000018 0.27 ± 0.07 0.61 ± 0.37      
SERPINA7 Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 0.077599 0.000400 0.31 ± 0.48 0.90 ± 0.30     
SLC12A7 Solute Carrier Family 12 (Potassium/Chloride Transporter), Member 7 0.051144 0.000148 0.36 ± 0.04 0.60 ± 0.31     
SPTA1 Spectrin, Alpha, Erythrocytic 1 0.008266 0.000007 0.32 ± 0.08 0.49 ± 0.15     
TNKS Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 0.077599 0.000401 0.38 ± 0.19 0.68 ± 0.33     
ZDHHC12 Zinc Finger, DHHC-Type Containing 12 0.075577 0.000332 0.17 ± 0.15 0.41 ± 0.27     
ZNF273 Zinc Finger Protein 273 0.092483 0.000527 0.10 ± 0.05 0.38 ± 0.42     
  1. FDR false discovery rate, G gene deleteriousness score, ION ion binding, ATP adenosine triphosphate binding, Ca2+ calcium-related, CP ciliopathy, PK pharmacokinetics–relate