Table 4 List of master-regulator molecules (including complexes and modified forms) that have passed all criteria
Master molecule name | Gene symbol | logFC | Composite score | Master Regulator Score | FDR | Z-Score | Ranks sum |
|---|---|---|---|---|---|---|---|
Cdk1(h) | CDK1 | 0.878 | 9.758 | 0.821 | 0.000 | 10.264 | 0 |
Cdk2(h) | CDK2 | 0.918 | 11.485 | 0.821 | 0.000 | 10.264 | 2 |
c-Fos(h) | FOS | 0.660 | 9.973 | 0.821 | 0.000 | 10.264 | 4 |
Chk1(h) | CHEK1 | 0.909 | 9.186 | 0.821 | 0.000 | 10.264 | 6 |
cyclinB1(h) | CCNB1 | 1.380 | 9.670 | 0.821 | 0.000 | 10.264 | 8 |
mTOR(h):raptor(h) | MTOR | 0.773 | 9.664 | 0.821 | 0.000 | 9.986 | 11 |
mTOR(h) | MTOR | 0.773 | 9.664 | 0.821 | 0.000 | 9.986 | 13 |
Chk1(h){pS345} | CHEK1 | 0.909 | 9.186 | 0.821 | 0.000 | 9.707 | 15 |
GSK3beta(h){p} | GSK3B | 0.937 | 9.181 | 0.821 | 0.000 | 4.971 | 15 |
E2-C(h) | UBE2C | 2.270 | 9.919 | 0.821 | 0.000 | 8.593 | 17 |
p70S6K1-alpha2(h) | RPS6KB1 | 0.658 | 9.644 | 0.821 | 0.000 | 3.857 | 33 |
cyclinA:Cdk2{pT160} | CDK2 | 0.918 | 11.485 | 0.672 | 0.008 | 4.320 | 34 |
GSK3beta(h){pS9} | GSK3B | 0.937 | 9.181 | 0.821 | 0.000 | 3.857 | 35 |
cyclinD:Cdk4{pT172} | CCND1 | 0.910 | 9.188 | 0.672 | 0.008 | 4.320 | 37 |
PKAc(h):GSK3beta(h) | GSK3B | 0.937 | 9.181 | 0.821 | 0.000 | 3.578 | 40 |
cyclinD1(h):Cdk4(h) | CCND1 | 0.910 | 9.188 | 0.672 | 0.014 | 3.931 | 42 |
securin(h) | PTTG1 | 0.979 | 9.606 | 0.821 | 0.000 | 3.578 | 42 |
cyclinD1:Cdk4:PAK1 | CCND1 | 0.910 | 9.188 | 0.672 | 0.014 | 3.905 | 45 |
Cdk4(h):cyclinD1a(h) | CCND1 | 0.910 | 9.188 | 0.672 | 0.014 | 3.852 | 47 |
cyclinE(h):Cdk2(h) | CDK2 | 0.918 | 11.485 | 0.672 | 0.022 | 3.510 | 56 |
p70S6K1(h){pT389} | RPS6KB1 | 0.658 | 9.644 | 0.821 | 0.000 | 2.185 | 89 |
p70S6K1(h) | RPS6KB1 | 0.658 | 9.644 | 0.821 | 0.000 | 1.628 | 146 |
H-Ras:GTP:Raf-1{p} | HRAS | 1.381 | 8.501 | 0.589 | 0.041 | 1.490 | 194 |