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Table 4 List of master-regulator molecules (including complexes and modified forms) that have passed all criteria

From: Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3

Master molecule name Gene symbol logFC Composite score Master Regulator Score FDR Z-Score Ranks sum
Cdk1(h) CDK1 0.878 9.758 0.821 0.000 10.264 0
Cdk2(h) CDK2 0.918 11.485 0.821 0.000 10.264 2
c-Fos(h) FOS 0.660 9.973 0.821 0.000 10.264 4
Chk1(h) CHEK1 0.909 9.186 0.821 0.000 10.264 6
cyclinB1(h) CCNB1 1.380 9.670 0.821 0.000 10.264 8
mTOR(h):raptor(h) MTOR 0.773 9.664 0.821 0.000 9.986 11
mTOR(h) MTOR 0.773 9.664 0.821 0.000 9.986 13
Chk1(h){pS345} CHEK1 0.909 9.186 0.821 0.000 9.707 15
GSK3beta(h){p} GSK3B 0.937 9.181 0.821 0.000 4.971 15
E2-C(h) UBE2C 2.270 9.919 0.821 0.000 8.593 17
p70S6K1-alpha2(h) RPS6KB1 0.658 9.644 0.821 0.000 3.857 33
cyclinA:Cdk2{pT160} CDK2 0.918 11.485 0.672 0.008 4.320 34
GSK3beta(h){pS9} GSK3B 0.937 9.181 0.821 0.000 3.857 35
cyclinD:Cdk4{pT172} CCND1 0.910 9.188 0.672 0.008 4.320 37
PKAc(h):GSK3beta(h) GSK3B 0.937 9.181 0.821 0.000 3.578 40
cyclinD1(h):Cdk4(h) CCND1 0.910 9.188 0.672 0.014 3.931 42
securin(h) PTTG1 0.979 9.606 0.821 0.000 3.578 42
cyclinD1:Cdk4:PAK1 CCND1 0.910 9.188 0.672 0.014 3.905 45
Cdk4(h):cyclinD1a(h) CCND1 0.910 9.188 0.672 0.014 3.852 47
cyclinE(h):Cdk2(h) CDK2 0.918 11.485 0.672 0.022 3.510 56
p70S6K1(h){pT389} RPS6KB1 0.658 9.644 0.821 0.000 2.185 89
p70S6K1(h) RPS6KB1 0.658 9.644 0.821 0.000 1.628 146
H-Ras:GTP:Raf-1{p} HRAS 1.381 8.501 0.589 0.041 1.490 194