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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Unearthing new genomic markers of drug response by improved measurement of discriminative power

Fig. 3

φ vs. -logPχ2 across all the 8637 drug-gene associations from GDSC. (Left) Number of drug-gene associations for each number of tested cell lines (n). Two distinctive groups of drugs emerge: those tested on around 300 cell lines (red bars) and those tested around 450 cell lines (black bars). (Right) φ versus -logPχ2 across the drug-gene associations (same colour code). The Spearman and Pearson correlations between both metrics are 0.99 and 0.82, respectively. The vertical blue line marks the significance cutoff for the chi-squared test. The plot shows that all markers with an φ of 0.15 or more are too discriminative to have arisen by chance (above an φ of 0.12 if we restrict to the markers evaluated with more data shown as black crosses)

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