Fig. 5
From: Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations
a STAT1 expression in single and multiple AETRIs at baseline and during exacerbation. b A TREM1 network is activated at baseline in subjects with multiple AETRIs. This network demonstrates a pro-inflammatory profile at baseline in subjects with multiple AETRIs. Several TLRs, MyD88 and other molecules associated with this TREM1 network are proinflammatory and may underlie the increased susceptibility to multiple AETRIs