Fig. 5

Modules identified by weighted co-expression network analysis on DEGs. a Topological overlap matrix (TOM) plot. Hierarchical clustering was applied to the TOM-based dissimilarity matrix to identify modules, i.e. groups of highly interconnected genes. The heatmap is a color-coded representation of the topological overlap between pairs of nodes. Each row/column corresponds to a gene and progressively darker red corresponds to higher topological overlap. The dendrogram and a color-coded module membership representation are shown to the left and above the heatmap. b Plots of expression profiles of genes in each of the six modules. Single gene profiles are shown in light grey, the black line corresponds to the median of module genes, the red area represents the interquartile range (25-75% of expression values) and the light blue area represents expression values of 90% of the data (5 - 95%). avMM: average module membership for genes in the module; N: number of genes in the module