Integrative analyses of genes and microRNA expressions in human trisomy 21 placentas

BMC Medical Genomics

Table 2 Expression changes of microRNA and genes showing negative correlation in the T21 placenta

Expression pattern of mRNAs in the T21 placenta	Gene Symbol	Fold intensity	P value	FDR	Chr	microRNAs showing negative correlation
Expression pattern of mRNAs in the T21 placenta	Gene Symbol	Fold intensity	P value	FDR	Chr	mir	Fold intensity	P value	FDR	Chr
Up-regulation	DYRK1A	1.530	0.013	0.008	21	mir-188-3p	4.301	0.004	0.007	X
	KSR1	1.805	0.013	0.006	17	mir-1301	6.571	0.016	0.046	2
	RDH13	1.634	0.016	0.018	19	mir-188-3p	4.301	0.004	0.007	X
	SETD4	1.696	0.007	0.009	21	mir-1301	6.571	0.016	0.046	2
	TTC3	1.678	0.037	0.045	21	mir-133b	5.470	0.001	0.001	6
	U2AF1	1.856	0.007	0.025	21	mir-133b	5.470	0.001	0.001	6
	ZNF614	1.615	0.043	0.040	19	mir-188-3p	4.301	0.004	0.007	X
Down-regulation	AGA	1.520	0.005	0.002	4	mir-513a-3p	4.192	0.013	0.040	X
	C4orf32	1.798	0.017	0.015	4	mir-504,	3.848	0.006	0.012	X
						mir-513a-3p	4.192	0.013	0.040	X
						mir-891b	4.407	0.014	0.041	X
	F2RL1	1.846	0.006	0.004	5	mir-513a-3p	4.192	0.013	0.040	X
	F2RL1	1.846	0.006	0.004	5	mir-1297	8.045	0.012	0.036	13
	HGF	2.404	0.020	0.014	7	mir-1297	8.045	0.012	0.036	13
	JAM3	1.885	0.032	0.013	11	mir-320c	2.558	0.002	0.002	18
	MAP3K5	1.617	0.033	0.029	6	mir-513a-3p	4.192	0.013	0.040	X
	MAP3K5	1.617	0.033	0.029	6	mir-891b	4.407	0.014	0.041	X
	MRPL43	2.611	0.020	0.016	10	mir-504	3.848	0.006	0.012	X
	PHLDA1	1.905	0.027	0.010	12	mir-513a-3p	4.192	0.013	0.040	X
						mir-891b	4.407	0.014	0.041	X
						mir-1297	8.045	0.012	0.036	13
	SUSD2	2.324	0.024	0.008	22	mir-1297	8.045	0.012	0.036	13
	TICAM2	1.604	0.043	0.033	5	mir-891b	4.407	0.014	0.041	X

rawP: p value from hypergeometric test, adjP: p value adjusted by the multiple test adjustment

ISSN: 1755-8794