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Table 1 Demographic, clinical phenotypes and environmental exposures of CAMP and CARE study participants

From: African ancestry is associated with cluster-based childhood asthma subphenotypes

  CAMP (N = 813) CARE(N = 398) p-value
Age, Mean (SD), years 8.9 (2.1) 10.6 (2.8) < 0.0001
Gender, No. (%)    0.8152
 Male 500 (61.5) 242 (60.8)  
 Female 313 (38.5) 156 (39.2)  
Race, No. (%)    < 0.0001
 Caucasian 557 (68.5) 215 (54)  
 African American 107 (13.2) 70 (17.6)  
 Hispanic 77 (9.5) 78 (19.6)  
 Other 72 (8.9) 35 (8.8)  
BMIZ at baseline, Mean (SD) 0.5 (1.0) 0.8 (1.0) < 0.0001
Age of onseta, Mean (SD), years 3.0 (2.4) 3.7 (3.3) < 0.0001
FEV1 PC20 methb, Mean (SD), mg/ml 2.0 (2.4) 2.2 (3.1) 0.3602
FEV1 percent predictedc, Mean (SD) 93.4 (14.1) 97.1 (12.8) < 0.0001
FVC percent predictedd, Mean (SD) 103.7 (13.1) 106.7 (12.2) 0.0002
FEV1/FVC ratioe, Mean (SD) 79.6 (8.3) 80.1 (8.0) 0.2937
Bronchodilator percent changef, Mean (SD) 10.7 (9.9) 9.4 (8.4) 0.0236
Blood eosinophils, Mean (SD), mm3 485.7 (409.2) 408.8 (319.5) 0.0011
IgE, Mean (SD), ng/ml 1129.8 (2081.9) 330.6 (445.4) < 0.0001
Average AM peak flowg, Mean (SD), L/min 250.9 (64.4) 271.1 (92.4) < 0.0001
Average AM symptomsh, Mean (SD) 0.61 (0.45) 0.51 (0.40) < 0.0001
Environmental smokei, No. (%) 339 (41.7) 166 (41.7) 0.0256
In utero smokej, No. (%) 107 (13.2) 54 (13.6) 0.8060
Atopic dermatitisk, No. (%) 199 (24.4) 155 (38.9) < 0.0001
One or more positive SPTl, No. (%) 716 (88.1) 312 (78.4) 0.0002
  1. aAge at first asthma symptoms
  2. bThe dose of methacholine that is required to decrease FEV1 by 20%
  3. cForced expiratory volume, the maximal amount of air one can forcefully exhale in one second converted to a percentage of normal based on one’s height, weight, body composition, and race
  4. dForced vital capacity, the amount of air a person can expire after a maximum inspiration second converted to a percentage of normal based on one’s height, weight, body composition, and race
  5. eAlso called Tiffeneau-Pinelli index, is a calculated ratio used in the diagnosis of obstructive and restrictive lung disease. It represents the proportion of a person’s vital capacity that they are able to expire in the first second of expiration
  6. fPost bronchodilator percent change from baseline: 100*(POSFEV - PREFEV)/PREFEV
  7. gThe maximum flow rate generated during a forceful exhalation, starting from full lung inflation; average of daily measurements up to 4 weeks prior to visit with a minimum of 7 days, recorded in daily diary card
  8. hMaximum of daily wheezing and coughing then average of daily measurements up to 4 weeks prior to visit with a minimum of 7 days, recorded in daily diary card
  9. iEither parent smoked during trial or home exposure to smoke prior to trial enrollment
  10. jMother smoked when pregnant with participant
  11. kChild had atopic dermatitis for 2 years and was seen by a doctor for it
  12. lOne or more skin prick test positive