Table 2 CAMP hierarchical clustering results
From: African ancestry is associated with cluster-based childhood asthma subphenotypes
|  | Cluster 1 (N = 98) | Cluster 2 (N = 171) | Cluster 3 (N = 544) | p-value |
|---|---|---|---|---|
Age (years) | 7.8 (1.9) | 8.7 (2.1) | 9.2 (2.1) | < 0.0001 |
Gender No. (%) | Â | Â | Â | 0.0675 |
 Male | 50 (51.0) | 105 (61.4) | 345 (63.4) |  |
 Female | 48 (49.0) | 66 (38.6) | 199 (36.6) |  |
Race No. (%) | Â | Â | Â | 0.0153 |
 Caucasian | 82 (83.7) | 116 (67.8) | 359 (66.0) |  |
 African American | 9 (9.2) | 25 (14.6) | 73 (13.4) |  |
 Hispanic | 5 (5.1) | 12 (7.0) | 60 (11.0) |  |
 Other | 2 (2.0) | 18 (10.5) | 52 (9.6) |  |
BMIZ | 0.7 (1.0) | 0.6 (1.1) | 0.5 (1.0) | 0.0929 |
Age of onset (years) | 2.4 (2.2) | 2.8 (2.2) | 3.2 (2.5) | 0.0017 |
FEV1 PC20 meth (mg/ml) | 2.9 (2.8) | 1.8 (2.2) | 2.0 (2.4) | 0.0005 |
FEV1 percent predicted | 96.3 (14.5) | 95.0 (14.5) | 92.4 (13.9) | 0.0117 |
FVC percent predicted | 103.5 (14.3) | 104.1 (13.6) | 103.6 (12.7) | 0.895 |
FEV1/FVC ratio | 82.9 (7.0) | 80.6 (8.2) | 78.7 (8.3) | < 0.0001 |
Bronchodilator percent change | 7.3 (6.9) | 11.4 (10.1) | 11.1 (10.1) | 0.0012 |
Blood eosinophils (mm3) | 228.9 (197.9) | 579.7 (442.4) | 504 (408.8) | < 0.0001 |
IgE (ng/ml) | 200.5 (449.1) | 1579 (2624.2) | 1161 (2022.7) | < 0.0001 |
Average AM peak flow (L/min) | 230.9 (55) | 249.8 (67.5) | 254.8 (64.4) | 0.0040 |
Average AM symptoms | 0.52 (0.40) | 0.61 (0.46) | 0.63 (0.45) | 0.100 |
Environmental smoke No. (%) | 42 (42.9) | 60 (35.1) | 237 (44.1) | 0.1291 |
In utero smoke No. (%) | 19 (19.4) | 11 (6.4) | 77 (14.2) | 0.0046 |
Atopic dermatitis No. (%) | 15 (15.3) | 167 (97.7) | 17 (3.1) | < 0.0001 |
Positive SPT No. (%) | 1 (1) | 171 (100) | 544 (100) | < 0.0001 |