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Table 4 Association between subphenotypes and number of prednisone bursts and any ER visit or hospitalizations since last visit

From: African ancestry is associated with cluster-based childhood asthma subphenotypes

Number of prednisone bursts since last visit

CAMP

Predicted number of event

Incident rate ratios

Subphenotype

Estimate (95% CI)

p-value

Subphenotypes

IRR (95% CI)

p-value

 1

0.10 (0.08, 0.13)

< 0.0001

2 vs. 1

2.63 (1.45, 2.70)

< 0.0001

 2

0.20 (0.16, 0.24)

 

3 vs. 1

2.04 (1.56, 2.70)

< 0.0001

 3

0.20 (0.18, 0.22)

 

3 vs. 2

1.02 (0.83, 1.27)

0.8153

CARE

Predicted number of event

Incident rate ratios

Subphenotype

Estimate (95% CI)

p-value

Subphenotypes

IRR (95% CI)

p-value

 1

0.08 (0.05, 0.14)

0.3534

2 vs. 1

0.93 (0.57, 1.54)

0.7880

 2

0.08 (0.05, 0.12)

 

3 vs. 1

1.19 (0.76, 1.89)

0.4420

 3

0.10 (0.07, 0.14)

 

3 vs. 2

1.28 (0.90, 1.82)

0.1666

Any ER visit or hospitalizations since last visit

CAMP

Predicted probability

Odds ratios

Subphenotype

Estimate (95% CI)

p-value

Subphenotypes

OR (95% CI)

p-value

 1

0.03 (0.02, 0.04)

0.1232

2 vs. 1

1.52 (0.95, 2.44)

0.0776

 2

0.04 (0.03, 0.05)

 

3 vs. 1

1.54 (1.01, 2.33)

0.0434

 3

0.04 (0.03, 0.04)

 

3 vs. 2

1.01 (0.75, 1.37)

0.9474

CARE

Predicted probability

Odds ratios

Subphenotype

Estimate (95% CI)

p-value

Subphenotypes

OR (95% CI)

p-value

 1

0.02 (0.01, 0.05)

0.0155

2 vs. 1

0.35 (0.13, 0.98)

0.0458

 2

0.01 (0.004, 0.02)

 

3 vs. 1

1.20 (0.56, 2.63)

0.6296

 3

0.03 (0.02, 0.04)

 

3 vs. 2

3.45 (1.47, 7.69)

0.0039