Table 1 Characteristics of PEAR and PEAR-2 participants classified as responder and non-responders for the RNA-Seq analysis

Age

48 ± 12

48 ± 8

53 ± 8

48 ± 10

52 ± 8

50 ± 10

Female, n (%)

11 (44%)

10 (40%)

15 (75%)^a

5 (25%)^a

12 (48%)

12 (48%)

BMI, kg^am^− 2

29 ± 5

32 ± 6

32 ± 5

30.5 ± 5

30 ± 6

31 ± 5

Baseline DBP

93 ± 5

94 ± 4

97 ± 6^a

93 ± 5^a

98 ± 6^a

93 ± 4^a

Baseline SBP

146 ± 10

144 ± 10

152 ± 11^a

144 ± 9^a

152 ± 10^a

146 ± 10^a

DBP response to TD

−9 ± 6^b

0.06 ± 4^b

− 14 ± 4^b

− 0.2 ± 2^b

− 17 ± 4^b

− 1.4 ± 3^b

SBP response to TD

−12 ± 6^b

− 0.9 ± 6^b

− 22 ± 7^b

− 1.5 ± 5^b

− 27 ± 7^b

− 4.4 ± 5^b