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Table 1 Characteristics of PEAR and PEAR-2 participants classified as responder and non-responders for the RNA-Seq analysis

From: Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies

  Whites (n = 99) Blacks (n = 50)
  HCTZ Chlorthalidone Chlorthalidone
Characteristics Responders (n = 24) Non-responders (n = 25) Responders (n = 25) Non-responders (n = 25) Responders (n = 25) Non-responders (n = 25)
Age 48 ± 12 48 ± 8 53 ± 8 48 ± 10 52 ± 8 50 ± 10
Female, n (%) 11 (44%) 10 (40%) 15 (75%)a 5 (25%)a 12 (48%) 12 (48%)
BMI, kgam− 2 29 ± 5 32 ± 6 32 ± 5 30.5 ± 5 30 ± 6 31 ± 5
Baseline DBP 93 ± 5 94 ± 4 97 ± 6a 93 ± 5a 98 ± 6a 93 ± 4a
Baseline SBP 146 ± 10 144 ± 10 152 ± 11a 144 ± 9a 152 ± 10a 146 ± 10a
DBP response to TD −9 ± 6b 0.06 ± 4b − 14 ± 4b − 0.2 ± 2b − 17 ± 4b − 1.4 ± 3b
SBP response to TD −12 ± 6b − 0.9 ± 6b − 22 ± 7b − 1.5 ± 5b − 27 ± 7b − 4.4 ± 5b
  1. Mean and Standard Deviation values for the continuous variables were presented
  2. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TD thiazide diuretics
  3. aSignificant at the 0.05 probability level
  4. bSignificant at the 0.001 probability level