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Table 5 Genes associated with multiple phenotypes, both acute and prognostic, in CD4 and CD8 T cells

From: Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Gene

Phenotype 1

Phenotype 2

Phenotype 3

CD4

ATP1A1

Temporal headache

Bilateral blindness

Death within 12 months

LAMTOR4

Temporal headache

Jaw claudication

Death within 12 months

MATR3

White cell count

Monocular blindness

Death within 12 months

MLH1

Temporal headache

Bilateral blindness

Death within 12 months

NDEL1

Loss of appetite

Other headache

Death within 12 months

NDUFS7

Temporal headache

Elevated lymphocytes

Death within 12 months

PDZD4

Fever

Loss of appetite

Reduced platelets

POFUT2

Temporal headache

Other headache

Death within 12 months

RRP1

Temporal headache

Bilateral blindness

Death within 12 months

SDCCAG3

Bilateral blindness

Relapse events

Death within 12 months

SEC23A

Fever

Reduced platelets

Death within 12 months

SLC10A3

Fever

Reduced white cell count

Death within 12 months

USF2

Temporal headache

Bilateral blindness

Death within 12 months

WDR91

Loss of appetite

Elevated white cell count

Death within 12 months

ZNF343

Scalp tenderness

Reduced neutrophils

Death within 12 months

CD8

ACADVL

Elevated neutrophils

Other headache

Death within 12 months

CD6

Elevated neutrophils

Visual disturbance

Death within 12 months

EIF5A

Malaise

Temporal headache

Death within 12 months

FDXR

Loss of appetite

Weight loss

Death within 12 months

INPPL1

Malaise

Fatigue

Elevated neutrophils

JMJD7

Temporal headache

Other headache

Death within 12 months

KIAA0513

Visual disturbance

Bilateral blindness

Death within 12 months

KLRC4-KLR1I

Temporal headache

Other headache

Death within 12 months

MTA1

Elevated neutrophils

Visual disturbance

Death within 12 months

NUCB2

Temporal headache

Bilateral blindness

Death within 12 months

PI4KA

Elevated neutrophils

Visual disturbance

Death within 12 months

PRAG1

Elevated neutrophils

Bilateral blindness

Death within 12 months

RNPS1

Malaise

Fatigue

Death within 12 months

SLC35F6

Temporal headache

Other headache

Death within 12 months

UQCRC1

Malaise

Other headache

Death within 12 months

ZNF708

Temporal headache

Other headache

Death within 12 months