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Table 5 Genes associated with multiple phenotypes, both acute and prognostic, in CD4 and CD8 T cells

From: Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Gene Phenotype 1 Phenotype 2 Phenotype 3
CD4
ATP1A1 Temporal headache Bilateral blindness Death within 12 months
LAMTOR4 Temporal headache Jaw claudication Death within 12 months
MATR3 White cell count Monocular blindness Death within 12 months
MLH1 Temporal headache Bilateral blindness Death within 12 months
NDEL1 Loss of appetite Other headache Death within 12 months
NDUFS7 Temporal headache Elevated lymphocytes Death within 12 months
PDZD4 Fever Loss of appetite Reduced platelets
POFUT2 Temporal headache Other headache Death within 12 months
RRP1 Temporal headache Bilateral blindness Death within 12 months
SDCCAG3 Bilateral blindness Relapse events Death within 12 months
SEC23A Fever Reduced platelets Death within 12 months
SLC10A3 Fever Reduced white cell count Death within 12 months
USF2 Temporal headache Bilateral blindness Death within 12 months
WDR91 Loss of appetite Elevated white cell count Death within 12 months
ZNF343 Scalp tenderness Reduced neutrophils Death within 12 months
CD8
ACADVL Elevated neutrophils Other headache Death within 12 months
CD6 Elevated neutrophils Visual disturbance Death within 12 months
EIF5A Malaise Temporal headache Death within 12 months
FDXR Loss of appetite Weight loss Death within 12 months
INPPL1 Malaise Fatigue Elevated neutrophils
JMJD7 Temporal headache Other headache Death within 12 months
KIAA0513 Visual disturbance Bilateral blindness Death within 12 months
KLRC4-KLR1I Temporal headache Other headache Death within 12 months
MTA1 Elevated neutrophils Visual disturbance Death within 12 months
NUCB2 Temporal headache Bilateral blindness Death within 12 months
PI4KA Elevated neutrophils Visual disturbance Death within 12 months
PRAG1 Elevated neutrophils Bilateral blindness Death within 12 months
RNPS1 Malaise Fatigue Death within 12 months
SLC35F6 Temporal headache Other headache Death within 12 months
UQCRC1 Malaise Other headache Death within 12 months
ZNF708 Temporal headache Other headache Death within 12 months