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Table 5 Sensitivity analysis for association of selected risk variants with GDM risk

From: Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women

SNP EA Chr Gene/nearest gene Location WHO 1999 WHO 2013 n
OR CI(lower) CI(upper) p-value n OR CI(lower) CI(upper) p-value
rs13266634a T 8 SLC30A8 coding-missense 1.24 1.01 1.53 0.037 2834 1.049 0.91 1.21 0.50 3837
rs11605924 A 11 CRY2 intron 0.84 0.71 0.99 0.038 2833 1.005 0.91 1.10 0.91 3848
rs35767 T 12 IGF1 nearGene-5 1.26 1.00 1.60 0.054 2837 1.15 0.98 1.33 0.07 3848
rs5219a T 11 KCNJ11 coding -missense 1.18 1.00 1.40 0.059 2605 1.00 0.91 1.11 0.91 3539
rs11708067a G 3 ADCY5 intron 1.11 0.86 1.44 0.42 2810 1.25 1.09 1.45 0.002 3816
rs689a A 11 INS Promoter/intron 0.91 0.64 1.29 0.60 2835 0.81 0.65 1.00 0.054 3842
rs8108269 G 19 GIPR intergenic 1.14 0.94 1.36 0.17 2568 1.12 0.99 1.25 0.059 3449
rs7756992a G 6 CDKAL1 intron 0.96 0.76 1.19 0.69 2670 2.80 1.00 7.87 0.049 3626
  1. aindicates loci previously associated with GDM / T2D in India or GDM in studies based on the European population
  2. Logistic regression was performed on GDM cases diagnosed according to WHO1999 and WHO2013 criteria against controls who had no GDM diagnosis using either criteria
  3. significant p values where p < 0.05 are indicated in bold