Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women

BMC Medical Genomics

Table 5 Sensitivity analysis for association of selected risk variants with GDM risk

SNP	EA	Chr	Gene/nearest gene	Location	WHO 1999					WHO 2013				n
SNP	EA	Chr	Gene/nearest gene	Location	OR	CI(lower)	CI(upper)	p-value	n	OR	CI(lower)	CI(upper)	p-value	n
rs13266634^a	T	8	SLC30A8	coding-missense	1.24	1.01	1.53	0.037	2834	1.049	0.91	1.21	0.50	3837
rs11605924	A	11	CRY2	intron	0.84	0.71	0.99	0.038	2833	1.005	0.91	1.10	0.91	3848
rs35767	T	12	IGF1	nearGene-5	1.26	1.00	1.60	0.054	2837	1.15	0.98	1.33	0.07	3848
rs5219^a	T	11	KCNJ11	coding -missense	1.18	1.00	1.40	0.059	2605	1.00	0.91	1.11	0.91	3539
rs11708067^a	G	3	ADCY5	intron	1.11	0.86	1.44	0.42	2810	1.25	1.09	1.45	0.002	3816
rs689^a	A	11	INS	Promoter/intron	0.91	0.64	1.29	0.60	2835	0.81	0.65	1.00	0.054	3842
rs8108269	G	19	GIPR	intergenic	1.14	0.94	1.36	0.17	2568	1.12	0.99	1.25	0.059	3449
rs7756992^a	G	6	CDKAL1	intron	0.96	0.76	1.19	0.69	2670	2.80	1.00	7.87	0.049	3626

^aindicates loci previously associated with GDM / T2D in India or GDM in studies based on the European population
Logistic regression was performed on GDM cases diagnosed according to WHO1999 and WHO2013 criteria against controls who had no GDM diagnosis using either criteria
significant p values where p < 0.05 are indicated in bold

ISSN: 1755-8794