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Table 3 Information on biological processes based on Gene ontology. Up-regulated proteins identified by proteomic analysis of positive lymph node samples. Proteins are referenced by their HGNC gene symbol

From: Differentially expressed proteins in positive versus negative HNSCC lymph nodes

Biological process Up-regulated proteinsa
Angiogenesis HSPB1
Apoptosis LGALS1, S100A9, SFN
 Anti-apoptosis ANXA1, GSTP1, HSPB1
Autophagy S100A9
Cell adhesion
 Cell-cell adhesion APOA1, POSTN
Cell communication
 Signaling ANXA1, APOA1, HSPB1, IGHG1, IGKC, LGALS1, S100A7, S100A9, SFN
 Cell-cell signaling S100A9
Cell growth
 Positive regulation of cell growth S100A9
Cell migration or movement
 Cell motility ANXA1, HSPB1, S100A9
Cytoskeleton organization KRT13, S100A9
Developmental process
 System development GSTP1, POSTN
 Cell differentiation ANXA1
 Epidermis development FABP5, S100A7, SFN
Metabolic process AKR1B10, APOA1, FABP5, GSTP1
 Protein metabolic process APOA1, CSTB
 Lipid metabolic process APOA1, FABP5
 Protein modification process GSTP1, SFN
Response to stimulus ANXA1, HSPB1
 Defense response KRT6A, S100A7, S100A9
 Inflammatory response ANXA1, APOA1, S100A9
 Immune response APOA1, IGHG1, IGKC
 Response to ROS GSTP1, S100A7
Transcription S100A9, SFN
Translation HSPB1
Transport APOA1
  1. aName of up-regulated proteins:AKR1B10 Aldo-keto reductase family 1 member B10, ANXA1 Annexin A1, APOA1 Apolipoprotein A-I, CSTB Cystatin-B, FABP5 Fatty acid-binding protein, epidermal, GSTP1 Glutathione S-transferase P, HSPB1 Heat shock protein beta-1, IGHG1 Ig gamma-1 chain C region, IGKC Ig kappa chain C region, KRT6A Keratin, type II cytoskeletal 6A, KRT13 Keratin, type I cytoskeletal 13, LGALS1 Galectin-1, POSTN Periostin, S100A7 Protein S100A7, S100A9 Protein S100A9, SFN 14–3-3 protein sigma