Skip to main content

Advertisement

Table 4 Information on biological processes based on Gene ontology. Down-regulated proteins identified by proteomic analysis of positive lymph node samples. Proteins are referenced by their HGNC gene symbol

From: Differentially expressed proteins in positive versus negative HNSCC lymph nodes

Biological process Down-regulated proteinsa
Apoptosis CALR, YWHAB
 Regulation of apoptosis HBA1/2, HBB, P4HB, PRDX2
 Anti-apoptosis ALB, ARHGDIA, HSP90B1, PARK7, PSMB5, YWHAZ
Cell adhesion ARHGDIA, ARHGDIB
Cell cycle
 Arrest CALR, PSMB5
Cell communication
 Signaling ACTB, ARHGDIA, ARHGDIB, CALR, HIST1H3A, HSP90B1, MYL6, PARK7, PSMB5, RAP1A, YWHAB, YWHAZ
Cell migration or movement ARHGDIA, ARHGDIB, PFN1, PPIA
 Cell motility ACTB
Cell proliferation
 Positive regulation CALR
Cytoskeleton organization ARHGDIB, PFN1
Developmental process ARHGDIB, MYL6
 System development PRDX1
 Cell differentiation CALR, RAP1A, TAGLN2
 Epidermis development KRT9
Metabolic process ALB, BLVRB, CA1, GAPDH, HBA1/2, HBB, P4HB, PARK7, PSMB5, RAP1A
 Protein metabolic process ACTB, CALR, P4HB, RAP1A
 Protein modification process ACTB, CALR, HBA1/2, HBB, HIST1H3A, HSP90B1, PARK7, PFN1, PPIA, PSMB5, YWHAB
 Monosaccharide metabolic process GAPDH, TPI1
Oxidation-reduction process HBA1/2, HBB
Response to stimulus HBA1/2, PARK7, RAP1A
 Defense response COTL1, HIST1H2BG, HIST1H3A
 Immune response ACTB, ARHGDIB, HIST1H2BG, HSP90B1, PSMB5, YWHAB
 Response to stress HSP90B1, P4HB
 Response to oxidative stress HBA1/2, HBB, PARK7, PRDX1, PRDX2, PRDX6
Replication
 DNA replication CALR, HIST1H3A, PPIA
Senescence CALR
Transcription CALR, HIST1H3A, PARK7, PRDX1, PRDX2, PSMB5, YWHAB, YWHAZ
Translation CALR, GAPDH
Transport ALB, CA1, HBA1/2, HBB, HBD, HSP90B1, RAB10, RAB5B, RAP1A
  1. aName of down-regulated proteins: ACTB Actin, cytoplasmic 1, ALB Serum albumin, ARHGDIA Rho GDP-dissociation inhibitor 1, ARHGDIB Rho GDP-dissociation inhibitor 2, BLVRB Flavin reductase (NADPH), CA1 Carbonic anhydrase 1, CALR Calreticulin, COTL1 Coactosin-like protein, GAPDH Glyceraldehyde-3-phosphate dehydrogenase, HBA1/2 Hemoglobin subunit alpha, HBB Hemoglobin subunit beta, HBD Hemoglobin subunit delta, HIST1H2BG Histone H2B type 1-C/E/F/G/I, HIST1H3A Histone H3.1, HSP90B1 Heat shock protein 90 kDa beta member 1, KRT9 Keratin, type I cytoskeletal 9, MYL6 Myosin light polypeptide 6, P4HB Protein disulfide-isomerase, PARK7 Protein deglycase DJ-1, PFN1 Profilin-1, PPIA Peptidyl-prolyl cis-trans isomerase A, PRDX1 Peroxiredoxin-1, PRDX2 Peroxiredoxin-2, PRDX6 Peroxiredoxin-6, PSMB5 Proteasome subunit beta type-5, RAB10 Ras-related protein Rab-10, RAB5B Ras-related protein Rab-5B, RAP1A Ras-related protein Rap-1A, TAGLN2 Transgelin-2, TPI1 Triosephosphate isomerase, YWHAB 14–3-3 protein beta/alpha, YWHAZ 14–3-3 protein zeta/delta