Table 4 Information on biological processes based on Gene ontology. Down-regulated proteins identified by proteomic analysis of positive lymph node samples. Proteins are referenced by their HGNC gene symbol
From: Differentially expressed proteins in positive versus negative HNSCC lymph nodes
Biological process | Down-regulated proteinsa |
|---|---|
Apoptosis | CALR, YWHAB |
 Regulation of apoptosis | HBA1/2, HBB, P4HB, PRDX2 |
 Anti-apoptosis | ALB, ARHGDIA, HSP90B1, PARK7, PSMB5, YWHAZ |
Cell adhesion | ARHGDIA, ARHGDIB |
Cell cycle | |
 Arrest | CALR, PSMB5 |
Cell communication | |
 Signaling | ACTB, ARHGDIA, ARHGDIB, CALR, HIST1H3A, HSP90B1, MYL6, PARK7, PSMB5, RAP1A, YWHAB, YWHAZ |
Cell migration or movement | ARHGDIA, ARHGDIB, PFN1, PPIA |
 Cell motility | ACTB |
Cell proliferation | |
 Positive regulation | CALR |
Cytoskeleton organization | ARHGDIB, PFN1 |
Developmental process | ARHGDIB, MYL6 |
 System development | PRDX1 |
 Cell differentiation | CALR, RAP1A, TAGLN2 |
 Epidermis development | KRT9 |
Metabolic process | ALB, BLVRB, CA1, GAPDH, HBA1/2, HBB, P4HB, PARK7, PSMB5, RAP1A |
 Protein metabolic process | ACTB, CALR, P4HB, RAP1A |
 Protein modification process | ACTB, CALR, HBA1/2, HBB, HIST1H3A, HSP90B1, PARK7, PFN1, PPIA, PSMB5, YWHAB |
 Monosaccharide metabolic process | GAPDH, TPI1 |
Oxidation-reduction process | HBA1/2, HBB |
Response to stimulus | HBA1/2, PARK7, RAP1A |
 Defense response | COTL1, HIST1H2BG, HIST1H3A |
 Immune response | ACTB, ARHGDIB, HIST1H2BG, HSP90B1, PSMB5, YWHAB |
 Response to stress | HSP90B1, P4HB |
 Response to oxidative stress | HBA1/2, HBB, PARK7, PRDX1, PRDX2, PRDX6 |
Replication | |
 DNA replication | CALR, HIST1H3A, PPIA |
Senescence | CALR |
Transcription | CALR, HIST1H3A, PARK7, PRDX1, PRDX2, PSMB5, YWHAB, YWHAZ |
Translation | CALR, GAPDH |
Transport | ALB, CA1, HBA1/2, HBB, HBD, HSP90B1, RAB10, RAB5B, RAP1A |