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Fig. 5 | BMC Medical Genomics

Fig. 5

From: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line

Fig. 5

Top 10 canonical pathways involved by the 41 significantly down-regulated genes in MMD-iPSECs. Graph showing the top 10 canonical pathways from IPA® pathway analysis involved by the 41 significantly down-regulated genes in MMD-iPSECs that were predicted as target genes of significantly up-regulated hsa-miR-328-3p and − 6722-3p in MMD-iPSECs. The ratio expresses the number of differentially down-regulated genes in our dataset over the total number of genes in each canonical pathway based on the IPA knowledge database (represented in the lower X axis). P values for the significance of each pathway were computed based on the number of genes involved in the pathway by using Fisher’s exact test, and negatively log10 transformed (represented in the upper X axis)

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