Comprehensive off-target analysis of dCas9-SAM-mediated HIV reactivation via long noncoding RNA and mRNA profiling

Table 2 21 genes that are significantly downregulated in the O samples as compared to the Zero and L samples

Genes	LTR_O_FPKM	LTR_Zero_FPKM	log₂(fold)	LTR_L_FPKM	log₂(fold)
HNRNPAB	6.55	38.66	− 2.56	43.94	−2.75
PTP4A2	3.62	20.44	−2.50	23.02	−2.67
B4GALT2	2.07	6.02	−1.54	6.07	−1.55
C4orf48	4.99	11.81	−1.24	11.15	−1.16
TPGS1	3.36	7.16	−1.09	8.80	−1.39
HPCAL1	4.01	8.33	−1.05	8.39	−1.06
SLBP	10.55	20.53	−0.96	20.64	−0.97
CITED4	3.56	6.79	−0.93	7.66	−1.11
HIST2H2BF	97.90	175.32	− 0.84	176.52	− 0.85
TMEM160	8.40	14.67	−0.80	16.45	−0.97
HIST2H2AC	444.08	750.59	−0.76	850.05	−0.94
C17orf89	57.82	95.66	−0.73	109.36	−0.92
IER5L	6.61	10.87	−0.72	13.23	−1.00
CEBPD	16.45	26.54	−0.69	29.57	−0.85
HIST2H3D	248.87	400.31	−0.69	425.10	−0.77
HIST1H2AB	336.25	536.04	−0.67	587.46	−0.80
HIST1H2AM	468.32	743.47	−0.67	809.48	−0.79
MIF	128.97	200.45	−0.64	247.69	−0.94
HIST1H4J	1102.07	1656.42	−0.59	1819.34	−0.72
CYBA	179.61	268.40	−0.58	308.07	−0.78
HIST1H2AD	722.53	1057.74	−0.55	1177.36	−0.70

ISSN: 1755-8794