Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes

Table 1 Genes with common variants (MAF < 10%) in all the members of a subgroup

Gene	Sub-group	Number of variants	Type of variants
TTN	Recessive	22	Non-synonymous
MON1B	Metabolic	1	Frameshift
NEDD4	Sensory	2	Non-synonymous
ZAN	Sensory	7	Six non-synonymous, one in-frame deletion

Details of the four genes found to be mutated in all members of a subgroup. TTN (underlined) is a candidate for exclusion

ISSN: 1755-8794