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Table 3 Mutation sites of mtDNA in MIEH individuals and controls

From: Mitochondrial DNA 7908–8816 region mutations in maternally inherited essential hypertensive subjects in China

Site of mutation Gene Replacement Number of mutations(n) Fisher’s exact P value Conservation (H/B/M/X)a Previously reportedb Change of Amino acid
(MIEH) (Controls)
8020 COXII G to A 1 0 1 G/T/C/G Yes non-synonymous variant
8027 COXII G to A 4 2 0.686 G/C/C/A Yes non-synonymous variant
8078 COXII G to A 2 1 1 G/G/A/C Yes non-synonymous variant
8149 COXII A to G 3 1 0.624 A/A/C/T Yes non-synonymous variant
8152 COXII G to A 2 0 0.499 G/A/C/C Yes non-synonymous variant
8176 COXII T to C 2 0 0.499 T/A/C/T Yes non-synonymous variant
8200 COXII T to C 5 1 0.216 T/T/T/C Yes non-synonymous variant
8251 COXII G to A 6 1 0.123 G/T/T/T Yes non-synonymous variant
8269 COXII G to A 2 1 1 G/A/A/C Yes non-synonymous variant
8348 tRNALys A to G 2 0 0.499 A/T/T/G Yes non-synonymous variant
8380 ATP8 T to C 1 0 1 T/T/C/C No non-synonymous variant
8392 ATP8 G to A 2 0 0.499 G/A/T/T Yes non-synonymous variant
8414 ATP8 C to T 60 7 9.883e-13 C/T/A/T Yes non-synonymous variant
8440 ATP8 A to G 1 0 1 A/C/C/T Yes non-synonymous variant
8452 ATP8 A to G 1 0 1 A/A/G/T No non-synonymous variant
8459 ATP8 A to G 4 1 0.373 A/T/C/G No non-synonymous variant
8467 ATP8 C to T 2 0 0.499 C/A/T/T No non-synonymous variant
8470 ATP8 A to G 2 0 0.499 A/C/A/T Yes non-synonymous variant
8473 ATP8 T to C 4 1 0.373 T/A/A/C Yes non-synonymous variant
8557 ATP8 G to A 1 0 1 G/C/G/T Yes non-synonymous variant
8563 ATP8 A to G 4 1 0.373 A/T/G/C Yes non-synonymous variant
8563 ATP8 A to T 1 0 1 A/T/G/C No non-synonymous variant
8584 ATP6 G to A 46 5 5.188e-10 G/T/C/A Yes non-synonymous variant
8593 ATP6 A to G 1 0 1 A/C/C/A No non-synonymous variant
8654 ATP6 T to C 1 0 1 T/A/A/G Yes non-synonymous variant
8656 ATP6 A to G 3 1 0.624 A/G/C/T No non-synonymous variant
8684 ATP6 C to T 9 2 0.063 C/G/T/T Yes non-synonymous variant
8701 ATP6 A to G 49 6 3.445e-10 A/A/T/A Yes non-synonymous variant
8723 ATP6 G to A 1 0 1 G/A/A/T No non-synonymous variant
8190 COXII C to T 1 0 1 C/T/A/A No synonymous variant
8343 tRNALys A to G 2 0 0.499 A/T/A/C Yes synonymous variant
8403 ATP8 T to C 1 0 1 T/A/G/C No synonymous variant
8409 ATP8 C to T 3 1 0.624 C/T/A/T No synonymous variant
8448 ATP8 T to C 2 0 0.499 T/A/C/G Yes synonymous variant
8503 ATP8 T to C 1 0 1 T/T/T/T Yes synonymous variant
8604 ATP6 T to C 1 0 1 T/C/A/A Yes synonymous variant
8614 ATP6 T to C 1 0 1 T/T/A/T Yes synonymous variant
8643 ATP6 C to T 1 0 1 C/C/C/T No synonymous variant
8745 ATP6 A to G 1 0 1 A/A/C/G No synonymous variant
8749 ATP6 T to C 1 0 1 T/A/T/T Yes synonymous variant
  1. aH/B/M/X means human/bovine/mouse/xenopus
  2. bSee http//www.mitomap.org and http://www.genpat.uu.se/mtDB/. Previously reported means the variant was ever reported in a database