Table 2 C-index of the Cox proportional hazards models based on different features
Feature type | Features | C-index | P-value |
|---|---|---|---|
Gene expression | 330 significant univariate genes | 0.584 | 0.0011 |
118 significant univariate genes with hazard ratio > 1.221 | 0.636 | <  0.0001 | |
88 significant univariate genes selected by GA | 0.656 | <  0.0001 | |
Somatic mutation | 25 functional annotations | 0.603 | 0.0012 |
15 gene ontology terms | 0.567 | 0.0013 | |
14 pathways | 0.548 | 0.0037 | |
54 functional gene sets combining functional annotations, GO terms and pathways | 0.591 | 0.0016 | |
Gene expression & somatic mutation | All 142 features (88 significant univariate genes and 54 functional gene sets) | 0.658 | <  0.0001 |