Fig. 1
From: Nucleotide excision repair is a predictor of early relapse in pediatric acute lymphoblastic leukemia
Comparative expression of the 20 canonical NER genes at diagnosis versus relapse. (A) In the Staal dataset (n = 27), 15 genes had higher expression at the time of relapse (gray bars) than at the time of diagnosis (black bars) (P = .006). 6 of these genes were individually significant: ERCC8 (P = .010), CCNH (P = .047), ERCC6 (P = .013), ERCC1 (P = .018), CDK7 (P = .020), and RAD23B (P = .022). (B) In the Hogan dataset (n = 49), 10 genes were overexpressed at time of relapse compared to at time of diagnosis (P = 1.000). 3 genes were individually significantly upregulated: DDB2 (P = .044), DDB1 (P < .001), and GTF2H3 (P = .005). * indicates P < .05 in a one tailed t-test