Fig. 3

NER gene expression of Early compared to Late Relapsers at diagnosis and at relapse. At diagnosis: (A) In Staal dataset 19 genes were increased in early (gray, n = 19) compared to late relapsers (black, n = 8) (P < .001). 6 genes were individually significantly overexpressed: CCNH (P = .031), DDB1 (P = .034), RPA1 (P = .015), ERCC3 (P = .031), XPC (P = .027) and RPA2 (P = 0.024). (B) In the Hogan dataset, 19 genes were overexpressed in early (n = 27) compared to late relapsers (n = 22, P < .001). 10 genes showed significant increases in expression: CCNH (P = .039), DDB1 (P = .002), DDB2 (P = .014), XPA (P = .031), ERCC2 (P = .048), RPA2 (P = .019), ERCC1 (P = .023), GTF2H2 (P = .041), ERCC8 (P = .014), and RPA3 (P = .005). (C) In the combined dataset, 19 genes were increased in early (n = 46) compared to late relapsers (n = 30, P < .001). 15 genes were significantly overexpressed: RAD23B (P = .040), DDB2 (P = .020), CCNH (P = .003), XPA (P = .029), DBB1 (P < .001), ERCC2 (P = .029), ERCC8 (P = .021), ERCC3 (P = .008), GTF2H4 (P = .016), XPC (P = .018), ERCC1 (P = .007), GTF2H2 (P = .012), RPA1 (P = .008), RPA3 (P = .004), and RPA2 (P = .001). At relapse: (D) In the Staal dataset 16 genes were overexpressed in early (n = 19) versus late relapsers (n = 8, P = .007). No gene was individually significant. (E) In Hogan, 8 genes had an increase in expression in early (n = 27) versus late relapsers (n = 22, P = .371). Two genes were significantly overexpressed: ERRC8 (P = .019) and CDK7 (P = .007). (F) In the combined dataset 13 genes exhibited an increase in expression in early (n = 46) versus late relapsers (n = 30, P = .180). 3 genes were significant: CCNH (P = .031), ERCC8 (P = .038), and CDK7 (P = .018). * indicates P < .05 in a one tailed t-test