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Fig. 1 | BMC Medical Genomics

Fig. 1

From: A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes

Fig. 1

Rationale underlying the pan-cancer analysis to identify (a) MDGs that are associated with genome-wide methylation changes across cancer types and (b) EDGs that are associated with genome-wide expression changes across cancer types, with further analysis that reveals (c) MDGs mostly consist of chromatin regulators that directly affect the genome-wide methylation patterns or genes that regulate expression of or physically interact with chromatin regulator.

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