Fig. 2

a Number of genome-wide hyper- (1) and hypo-methylated (2) sites that are associated with the mutation status of the 32 identified MDGs (columns) for each of the 20 TCGA tumor types (rows). (b) Number of genome-wide up-regulated- (1) and down-regulated- (2) genes that are associated with the mutation status of the 29 identified EDGs (columns) for each of the 20 TCGA tumor types (rows). The color code represents the number of differentially methylated sites/differentially expressed genes. Only driver genes that were mutated in ≥ 5 samples for the given tumor type were colored