Fig. 4
The top 10 most desirable genes have a wide range of desirabilities across data types. The top 10 genes from our iR-none analysis have overall desirabilities ranging from 0.38 (ACTN1) to 0.46 (CAPZB), but the dstudy values range, even when organized by data type. Some genes, like STOM, appear to be highly ranked not because of any extremely high dstudy value, but rather due to a lack of low dstudy values in any data type. In other words, this gene is likely not identified as particularly important in any individual study but shows a consensus of relatively strong evidence across all 10 studies. Contrastingly, other genes, like CAPZB, appear to be highly ranked due to one very high desirability score in a single data type (GWAS) that overpowers underwhelming evidence in other studies