Fig. 2

Convergent downstream genetic mechanisms predicted from shared eQTL RNA between disease-pairs are enriched among comorbidities observed in clinical datasets. Vertical axis = odds ratio of overrepresentation of shared molecular mechanisms among clinical comorbidities (Results-Convergent genetic mechanisms between disease-pairs are enriched among comorbid disease). Left bottom axis = FDR cutoffs of comorbidities found in the HCUP clinical datasets (OR > 3; Results- Prioritized comorbidities), right bottom axis = FDR cutoffs of shared molecular mechanisms discovered between two diseases