Table 2 Linkage analysis confirmed X-linkage in 3 familial cases of intellectual disability
Family | Linkage interval | Mbp | LOD | |
|---|---|---|---|---|
L020 (or 5X, or MRX51) | Initial | chrX:41,323,975-46,534,411 | 5.21 | 2.406 |
Refined | chrX:42,505,938-46,534,357 | 4.03 | 2.41 | |
L061 (or 37SX) | Initial | chrX:46,179,305-103,255,350 | 57.08 | 2.23 |
chrX:103,255,350-112,506,789 | 9.25 | 2.23 | ||
chrX:112,516,866-120,180,324 | 7.66 | 2.23 | ||
L084 (or 78X) | Initial | chrX:142,184,383-146,607,898 | 4.42 | 0.932 |
Refined | chrX:143,125,342-146,175,617 | 3.05 | 1.042 | |