Fig. 6

CNVs as predictive biomarker for chemotherapy in pediatric sarcoma. Gene IGF1R and clofarabine response provide an example of data integration. IGF1R gene amplification correlates with increasing sensitivity to clofarabine in pediatric sarcoma. a Correlation of IGF1R CNV and relative sensitivity to clofarabine. The IGF1R CNV status (deletion or amplification) for each cell line is presented in the middle of the panel (Del = gene deletion denoted in green; Amp = gene amplification denoted in red). The y axis signifies the response of each cell line to clofarabine and is presented as the area under the curve (AUC) to drug response. Blue circles = cell lines with IGF1R deletion; Red circles = cell lines with IGF1R amplification (left panel); Drug response data compiled as non-sensitive (NS) versus sensitive (S) cell lines,*p < 0.01, IGF1R deletion vs. IGF1R amplification, right panel b Strong linear correlation between IGF1R CNV and clofarabine response. Blue circles = cellular response to clofarabine; y-axis = AUC and x-axis = CNV of IGF1R. (c) CNVs as chemotherapy biomarkers in sarcoma. The sensitive and non-sensitive biomarker selection is based on the threshold where a threshold of p < 0.05 and correlation coefficient r > 0.35 denotes non-sensitivity and r < − 0.35 signifies sensitivity