Fig. 5
From: Predicting drug response of tumors from integrated genomic profiles by deep neural networks
Pharmacogenomics analysis of docetaxel and CX-5461 in TCGA. (a) Waterfall plot of predicted IC50 for the two drugs across all TCGA samples. Tumors with extreme IC50 values (top and bottom 1%) were denoted as the resistant and sensitive groups. (b) Cancer type composition of resistant and sensitive samples. Cancer types accounted for at least 10% in any group are highlighted in bold and shown in (c). (c) Heatmaps of cancer type composition, top differentially mutated genes, and top differentially expressed genes between the two groups. In the expression heatmap, genes are normalized and hierarchically clustered, and samples are clustered within each group