Table 3 Top gene mutations modulating pan-cancer drug response
From: Predicting drug response of tumors from integrated genomic profiles by deep neural networks
Gene | Mutation rate | Num. modulated drugs | Num. sensitive drugs | Num. resistant drugs |
|---|---|---|---|---|
TP53 | 34.3% | 251 | 9 | 242 |
CSMD3 | 12.6% | 223 | 12 | 211 |
SYNE1 | 11.5% | 218 | 10 | 208 |
TTN | 30.2% | 206 | 44 | 162 |
RYR2 | 11.9% | 199 | 14 | 185 |
USH2A | 10.7% | 191 | 12 | 179 |
LRP1B | 12.1% | 188 | 19 | 169 |
FLG | 11.0% | 183 | 9 | 174 |
MUC16 | 19.5% | 161 | 51 | 110 |
PCLO | 10.5% | 155 | 12 | 143 |
PIK3CA | 11.7% | 144 | 45 | 99 |