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Table 3 Top gene mutations modulating pan-cancer drug response

From: Predicting drug response of tumors from integrated genomic profiles by deep neural networks

Gene Mutation rate Num. modulated drugs Num. sensitive drugs Num. resistant drugs
TP53 34.3% 251 9 242
CSMD3 12.6% 223 12 211
SYNE1 11.5% 218 10 208
TTN 30.2% 206 44 162
RYR2 11.9% 199 14 185
USH2A 10.7% 191 12 179
LRP1B 12.1% 188 19 169
FLG 11.0% 183 9 174
MUC16 19.5% 161 51 110
PCLO 10.5% 155 12 143
PIK3CA 11.7% 144 45 99