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Table 3 “Within Patient” analysis: Association between changes in gene signature and changes in disease activity between two visits from the same persona,b

From: Association between changes in gene signatures expression and disease activity among patients with systemic lupus erythematosus

  IFN M1.2 IFN M3.4 IFN M5.12 BAFF LDG Plasma Cell
Estimate
(95% CI)
p value Estimate
(95% CI)
p value Estimate
(95% CI)
p value Estimate
(95%CI)
p value Estimate
(95% CI)
p value Estimate
(95% CI)
p value
PGA 0.11
(− 0.03, 0.25)
0.12 0.09
(− 0.02, 0.19)
0.10 0.05
(− 0.04, 0.15)
0.28 0.02
(− 0.06, 0.10)
0.64 − 0.06
(− 0.17, 0.05)
0.29 0.07
(− 0.01, 0.15)
0.074
SLEDAI 0.35
(− 0.26, 0.97)
0.26 0.31
(−0.15, 0.77)
0.18 0.29
(−0.13, 0,71)
0.17 0.16
(−0.20, 0.53)
0.38 −0.06
(− 0.54, 0.42)
0.80 0.45
(0.10, 0.80)
0.011
SLEDAI Vascular 0.02
(−0.01, 0.06)
0.25 0.01
(−0.01, 0.04)
0.34 0.01
(−0.02, 0.03)
0.45 0.01
(−0.01, 0.03)
0.33 −0.00
(− 0.03, 0.03)
0.97 0.01
(− 0.01, 0.03)
0.27
SLEDAI MUSCULOSKELETAL 0.02
(−0.03, 0.07)
0.36 0.02
(−0.02, 0.06)
0.34 0.01
(−0.02, 0.05)
0.41 0.01
(−0.02, 0.04)
0.58 −0.01
(− 0.05, 0.03)
0.65 0.01
(− 0.02, 0.04)
0.65
SLEDAI Renal 0.03
(−0.06, 0.11)
0.54 0.03
(−0.03, 0.09)
0.36 0.05
(−0.01, 0.11)
0.078 0.02
(−0.03, 0.07)
0.36 0.03
(−0.03, 0.10)
0.33 0.02
(−0.03, 0.06)
0.54
SLEDAI Skin −0.03
(− 0.11, 0.06)
0.53 − 0.00
(− 0.07, 0.06)
0.88 −0.02
(− 0.07, 0.04)
0.60 −0.04
(− 0.09, 0.01)
0.15 0.03
(− 0.03, 0.10)
0.31 0.02
(− 0.02, 0.07)
0.31
SLEDAI Hematologic −0.04
(− 0.07, − 0.01)
0.0095 −0.03
(− 0.05, − 0.01)
0.0096 −0.03
(− 0.05, − 0.01)
0.014 −0.02
(− 0.04, − 0.00)
0.028 −0.03
(− 0.06, − 0.01)
0.0060 0.01
(− 0.02, 0.03)
0.36
SLEDAI Immunology 0.00
(− 0.08, 0.09)
0.92 0.00
(− 0.06, 0.06)
0.96 −0.02
(− 0.08, 0.03)
0.42 0.00
(− 0.05, 0.05)
0.97 −0.08
(− 0.14, − 0.01)
0.026 0.09
(0.04, 0.14)
0.0002
Urine Protein Creatinine Ratio 0.06
(−0.07, 0.19)
0.36 0.05
(−0.05, 0.15)
0.32 0.05
(−0.04, 0.13)
0.31 0.06
(−0.02, 0.14)
0.12 −0.04
(− 0.14, 0.06)
0.44 0.05
(− 0.02, 0.13)
0.17
Log Anti-dsDNA 0.05
(−0.16, 0.25)
0.65 0.05
(−0.10, 0.20)
0.52 −0.01
(− 0.15, 0.13)
0.94 0.03
(− 0.09, 0.15)
0.65 −0.05
(− 0.21, 0.11)
0.56 0.20
(0.08, 0.32)
0.0008
C3 1.28
(− 3.56, 6.11)
0.60 1.99
(− 1.66, 5.63)
0.28 2.57
(−0.75, 5.88)
0.13 −0.20
(− 3.07, 2.67)
0.89 5.71
(1.90, 9.51)
0.0034 −3.60
(− 6.38, − 0.81)
0.011
C4 0.73
(−0.35, 1.82)
0.18 0.52
(−0.30, 1.34)
0.21 0.57
(−0.18, 1.31)
0.14 0.18
(−0.47, 0.83)
0.58 1.05
(0.19, 1.90)
0.017 −1.39
(−2.01, −0.77)
< 0.0001
ESR 2.19
(− 1.17, 5.55)
0.20 2.25
(−0.28, 4.78)
0.082 2.43
(0.13, 4.73)
0.039 −0.14
(−2.15, 1.87)
0.89 2.05
(−0.63, 4.73)
0.13 3.75
(1.81, 5.70)
0.0002
  1. aThe entries in the table represent the expected change in disease activity measure per 1 standard deviation change in the gene signature. Bolded enteries had p-values less than 0.05
  2. bAll the associations are adjusted for prednisone use, age, sex and race