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Table 1 Characteristics of reciprocal chromosome translocations (RCTs) carriers, including two familial cases (T10-T13) of fathers and sons

From: Chromosome (re)positioning in spermatozoa of fathers and sons – carriers of reciprocal chromosome translocation (RCT)

RCT Karyotype Seminal parametersb % of genetically unbalanced spermatozoab % of deprotaminated spermatozoa (AB)b % of spermatozoa with fragmented DNA (TUNEL)b Hyperhaploidy ratio in spermatozoa (%; enumerated only results higher than Mean Control values)b
T1 46,XY,t(1;11)(p36.22;q12.2)a N 59.6 nd 8.80 4–0.34; 8–0.40; 10–0.31; XY – 0.50
T2 46,XY,t(2;8)(q21;q22) T 54.3 28.5 18.8 10–0.22; 11–0.14; XY – 0.73
T3 46,XY,t(2;10)(q13;q24.3) N 50.7 66.3 35.8 7–0.22; 8–0.48; 18–0.53; XY – 0.62
T4 46,XY,t(3;9)(q27;q22.3) AT 43.0 22.0 7.6 4–0.51; 7–0.26; 8–0.60; 11–0.18; 18–0.56; XY – 0.33
T5 46,XY,t(4;10)(q35;q23.2) N 39.4 36.5 5.9 7–0.29; 18–0.64; XY – 0.16
T6 46,XY,t(4;18)(q33;q22.3) N 42.3 nd 34.1 8–0.20; 9–0.32; 10–0.15
T7 46,XY,t(6;14)(q21;q13.3) N 45.1 25.4 19.2 4–0.25; 7–0.29; 8–0.31; 9–0.37; 11–0.60; 18–0.59; XY – 0.29
T8 46,XY,t(7;18)(q11.23;q12.2) N 65.7 45.6 5.6 11–0.22
T9 46,XY,t(11;13)(p15.5;q22) O 45.0 22.2 19.7 10–0.21; 18–0.32; XY – 0.36
Familial case no. 1:
 T10 father 46,XY,t(4;5)(p15.1;p12)c N 65.2 4.6 nd 10–0.17; 18–0.22; XX – 0.25; YY – 0.18; XY – 0.33
 T11 son T 65.6 13.7 nd 18–0.29; XY – 0.26
Familial case no. 2:
 T12 father 46,XY,t(7;10)(p21.2;q26.13) N 37.6 nd 25.9 4–0.58; 8–0.28; XY – 0.31
 T13 son N 44.4 25.1 5.6 9–0.22; XY – 0.48
Mean RCT value ± SD 50.61 ± 16.78 28.99 ± 18.55* 17.00 ± 11.85*  
Mean Control value ± SDd 16.53 ± 7.89 8.41 ± 3.39 4–0.13; 7–0.13; 8–0.13; 9–0.12; 10–0.09; 11–0.08; 18–0.09; XX – 0.11; YY – 0.10; XY – 0.08
  1. N normozoospermia, T teratozoospermia, AT asthenoteratozoospermia, O oligozoospermia (according to WHO, 2010)
  2. AB aniline blue assay, TUNEL Terminal deoxynucleotidyl transferase dUTP Nick End Labeling, nd not done
  3. *value statistically significant according to Mean Control value (p < 0.05)
  4. apreviously published in Midro et al., 2014, except TUNEL and hyperhaploidy results
  5. bpreviously published in Olszewska et al., 2013, 2017 (T2-T9, T12-T13)
  6. cpercentage of genetically unbalanced spermatozoa previously published in Wiland et al., 2007
  7. dpreviously published in Olszewska et al., 2014 (hyperhaploidies), 2017 (AB, TUNEL)