Table 8 The cancer hallmarks mapping of the ten genes

CTSZ

IL2/JAK/STAT5 signaling

sustaining proliferative signaling, activating invasion and metastasis

[54]

EFEMP2

Epithelial mesenchymal transition

sustaining proliferative signaling, activating invasion and metastasis

[49]

ITGA5

Epithelial mesenchymal transition, Inflammatory response

All

[55]

KDELR2

activating invasion and metastasis

[56]

MDK

Estrogen response late, Apical junction

sustaining proliferative signaling, activating invasion and metastasis

[57]

MICALL2

sustaining proliferative signaling

[58]

MAP 2 K3

TNF-a signaling via NF-kB, PI3K/AKT/mTOR signaling, mTORC1 signaling, Heme metabolism

sustaining proliferative signaling

[59]

PLAUR

TNF-alpha signaling via NF-kB, Cholesterol homeostasis

activating invasion and metastasis, inducing angiogenesis

[52, 60,61,62]

SERPINE1

TNF- alpha signaling via NF-kB, Hypoxia, TGF-beta signaling, Complement, Epithelial mesenchymal transition, Inflammatory response, Xenobiotic metabolism, UV response down, Coagulation

inducing angiogenesis

[63]

SOCS3

TNF- alpha signaling via NF-kB, IL6/JAK/STAT3 signaling, Interferon gamma response

sustaining proliferative signaling, tumor-promoting inflammation

[64]