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Table 8 The cancer hallmarks mapping of the ten genes

From: Identification of potential biomarkers related to glioma survival by gene expression profile analysis

Gene symbol MSigDB (Hallmark) [53] Hallmarks of cancer Ref.
CTSZ IL2/JAK/STAT5 signaling sustaining proliferative signaling, activating invasion and metastasis [54]
EFEMP2 Epithelial mesenchymal transition sustaining proliferative signaling, activating invasion and metastasis [49]
ITGA5 Epithelial mesenchymal transition, Inflammatory response All [55]
KDELR2   activating invasion and metastasis [56]
MDK Estrogen response late, Apical junction sustaining proliferative signaling, activating invasion and metastasis [57]
MICALL2   sustaining proliferative signaling [58]
MAP 2 K3 TNF-a signaling via NF-kB, PI3K/AKT/mTOR signaling, mTORC1 signaling, Heme metabolism sustaining proliferative signaling [59]
PLAUR TNF-alpha signaling via NF-kB, Cholesterol homeostasis activating invasion and metastasis, inducing angiogenesis [52, 60,61,62]
SERPINE1 TNF- alpha signaling via NF-kB, Hypoxia, TGF-beta signaling, Complement, Epithelial mesenchymal transition, Inflammatory response, Xenobiotic metabolism, UV response down, Coagulation inducing angiogenesis [63]
SOCS3 TNF- alpha signaling via NF-kB, IL6/JAK/STAT3 signaling, Interferon gamma response sustaining proliferative signaling, tumor-promoting inflammation [64]