The molecular mechanisms driving physiological changes after long duration space flights revealed by quantitative analysis of human blood proteins

Table 2 Proteins with increased or stable concentration at R + 1

Protein name	Means, fmol/μl			Complement component	Acute phase proteins	Proteases	Protease inhibitors
Protein name	L-30	R + 1	R + 7	Complement component	Acute phase proteins	Proteases	Protease inhibitors
Alpha-1-antichymotrypsin	2392.5	2411.6	2473.1		+		+
Apolipoprotein B-100	474.9	478.1	415.9
Apolipoprotein E	797.9	914.5	915.8
Beta-2-glycoprotein 1	3367.2	3387.3	3471.1
C4b-binding protein alpha chain	208.1	208.9	211.1
Carbonic anhydrase 1	55.4	69.9	56.8
Ceruloplasmin	2158.3	2182.9	2292.2		+
Coagulation factor XI	46.9	49.3	46.2	+		+
Complement C2	108.4	109.5	110.0	+		+
Complement C3	5936.4	5986.7	6141.2	+	+	+
Complement C4-B	1639.5	1651.7	1691.3	+		+
Complement component C9	215.0	252.3	247.2	+	+
Fibrinogen alpha chain	6781.9	7651.4	7726.8	+	+
Fibrinogen beta chain	419.0	423.5	428.7	+	+
Fibrinogen gamma chain	426.4	480.3	490.1	+	+
Fibrinopeptide A	1469.0	1593.3	1663.9
Haptoglobin	18,033.4	19,230.8	19,612.7		+	+
Hemoglobin subunit alpha	2628.5	3248.1	2452.5
Insulin-like growth factor-binding protein complex acid labile subunit	143.3	156.9	148.1
Leucine-rich alpha-2-glycoprotein	271.2	321.2	308.2
Lipopolysaccharide-binding protein	121.1	126.8	119.4		+
MRNA for apolipoprotein E	677.4	790.8	778.8
Plasma serine protease inhibitor (PAI-3)	89.9	91.8	104.7	+			+
Protein AMBP	926.0	1007.6	1080.5				+
Protein S100-A9	2.7	6.2	3.8
Serum paraoxonase/lactonase 3	20.0	20.2	18.8
Thyroxine-binding globulin	166.9	173.6	171.6				+
Vitamin D-binding protein	3222.1	3301.9	3306.5
Vitamin K-dependent protein C	40.4	40.6	41.5	+		+
Vitronectin	325.1	326.4	352.1

ISSN: 1755-8794