Skip to main content

Table 6 Cox proportional hazards model for our dataset. In each calculation number of samples is 115

From: Genes CEP55, FOXD3, FOXF2, GNAO1, GRIA4, and KCNA5 as potential diagnostic biomarkers in colorectal cancer

n = 115 Univariate analysis Multivariate analysis
Clinical data Hazard ratio 95% confidence interval p-value Hazard ratio 95% confidence interval p-value (p-value of model)
Age (≥60) 1.967 1.01–3.833 0.043 2.825 1.330–6.000 0.007 (8.737e-12)
Gender (Male vs. Female) 1.544 0.982–2.426 0.058    
Metastasis presence 6.900 3.392–14.04 8.982e-10 6.692 3.137–14.278 8.8e-07 (8.737e-12)
Lymph node infiltration 2.016 1.367–2.975 3.366e-4 2.234 1.352–3.691 0.002 (8.737e-12)
Tumor size (T3/T4 vs. T1/T2) 1.867 1.143–3.048 0.011    
Location (rectum vs. colon) 1.797 1.139–2.836 0.011 2.047 1.212–3.457 0.007 (8.737e-12)
Late stage vs. early stage 1.926 1.172–3.165 0.009    
RT 1.134 0.534–2.409 0.743    
Chemotherapy 1.148 0.653–2.018 0.632    
Cancer progression 2.573 1.583–4.184 8.385e-05    
Methylation (methylated vs unmethylated)
 CEP55 1.276 0.312–5.217 0.734    
 FOXD3 ND      
 FOXF2 1.335 0.579–3.077 0.500    
 GNAO1 ND      
 GRIA4 0.339 0.106–1.092 0.05729    
 KCNA5 0.0704 0.009–0.572 0.001    
Expression (upregulated vs down-regulated)
 CEP55 ND      
 FOXD3 1.664 0.485–5.702 0.413    
 FOXF2 0.267 0.034–2.086 0.176    
 GNAO1 4.277 0.4992–36.65 0.148    
 GRIA4 4.478 0.4999–40.11 0.142    
 KCNA5 3.699 0.9577–14.29 0.042    
  1. ND not determinable