Exome-wide search and functional annotation of genes associated in patients with severe tick-borne encephalitis in a Russian population

Table 2 Genetic variants found in eight genes shared by the cases_only (2407 genes) set and the associated_harmful (46 genes) set

Gene	Harmful genetic variants found in patients with TBE, that are not common in non-Finnish European populations						Harmful genetic variants associated with severe forms of TBE
Gene	SNP ID or SNV position^a	Exonic function	SIFT	Polyphen2 HDIV	Polyphen2 HVAR	N ^b	SNP ID	P-value	Exonic function	SIFT	Polyphen2 HDIV
MAP4 ^c	rs150907099	nonsyn	D	D	D	1	rs11711953	0.001927	nonsyn	D	D
MAP4 ^c	rs150907099	nonsyn	D	D	D	1	rs2230169	0.005399	nonsyn	D	D
WDFY4	chr10:50,034,917	nonsyn	D	D	D	1	rs41283283	0.003018	nonsyn	T	D
ACTRT2	rs137950147	nonsyn	T	D	P	1	rs3795263	0.009637	nonsyn	D	D
KLHL25	rs779814173	nonsyn	D	B	B	1	rs35582838	0.009274	nonsyn	D	B
MAP2K3	rs141390631	nonsyn	D	P	D	1	rs74575904	0.002442	nonsyn	D	D
MBD1	rs183864846	nonsyn	D	B	B	1	rs125555	0.009685	nonsyn	D	P
OR10J1	rs35634161	nonsyn	D	D	D	2	rs12048482	0.003306	nonsyn	D	D
OR10J1	rs35634161	nonsyn	D	D	D	2	rs12409540	0.005492	stopgain	.	.
OR2T34	rs202166093	nonsyn	D	D	D	1	rs199863869	0.001284	nonsyn	D	B

^aSNV genomic position was determined according to the GRCh37/hg19 assembly
^bN - the occurrence of the rare harmful minor alleles harbored by certain gene in exomes of TBE patients (see Methods section)
^cMAP4 has PPI with one gene (IL7R) from the TBEVHostDB

ISSN: 1755-8794