Exome-wide search and functional annotation of genes associated in patients with severe tick-borne encephalitis in a Russian population

Table 3 Genes from the cases_only set and the associated set, which are characterized in the TBEVHostDB

Gene	Functional group of genes from the TBEVHostDB ^a	Reference from the TBEVHostDB	Number of polymorphisms per gene ^b
Cases_only set of genes
TLR3	Allelic variant	[38, 44]	3
TYK2	Physical interaction	[69]	1
FAM184A	Physical interaction	[69]	1
PHC2	Physical interaction	[69]	1
TJP2	Physical interaction	[70]	1
SCRIB	Physical interaction	[71]	1
ITGB3	Physical interaction	[72]	1
A2M	Up- or down-regulated	[73]	2
HMOX1	Up- or down-regulated	[74]	1
ICAM3	Up- or down-regulated	[75]	1
IFIH1	Up- or down-regulated	[19]	1
IL12B	Up- or down-regulated	[76]	2
HSPA1A	Up- or down-regulated	[77]	1
IL2RA	Up- or down-regulated	[78]	1
IFIT1	Up- or down-regulated	[79]	1
CXCL12	Up- or down-regulated	[17]	1
ICAM1	Up- or down-regulated	[78]	1
LTF	Up- or down-regulated	[80]	2
GFAP	Up- or down-regulated	[81]	1
Associated set of genes
TJP2	Physical interaction	[70]	1
ATF6	Up- or down-regulated	[77]	1
ARID1B	Allelic variant	[45]	1

^aAllelic variant, Allelic variant in this gene was associated with susceptibility or resistance to TBEV infection; Physical interaction, Genes encoding proteins that had direct physical interactions with TBEV virion, TBEV proteins or TBEV RNA; Up- or down-regulated, Genes encoding mRNAs (or proteins) that were up- or down-regulated in response to TBEV infection
^bFor genes from the cases_only set the number of loci occupied by harmful variants that are not common in non-Finnish Europeans is given. For genes from the associated set the number of variants of any types associated with severe forms of TBE at significance level of 0.01 is given

ISSN: 1755-8794