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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson’s, Alzheimer’s and ALS disease

Fig. 2

APA Regulation in Different Regions of the Brain in AD. a Significant 3’UTR lengthening (* = p < 0.01, Fisher’s exact Test) is observed in the frontal lobe and temporal lobe regions of the brain using DaPars analysis (PDUI > 0.25, Fisher’s exact Test < 0.05). Red and green bars indicate number of identified UTR-APA lengthening and shortening events respectively. The number of identified APA events in the comparison are indicated by n below the graph. b Venn diagram highlighting that different genes undergo APA in different regions of the brain and 14 genes show the same movements in both frontal (purple) and temporal lobe (blue). c Table to highlight the biological processes that were identified through Gene Ontology Analysis using the PANTHER platform in the genes that showed 3’UTR lengthening in either cohort. d Genome browser view of the 3’UTR lengthening in BIN1 in AD (AD, blue tracks) compared to control (C, green tracks). e. 3’UTR shortening in VAMP2 in AD (blue tracks) compared to control (C, green tracks). In d & e, the proximal and distal PAS’s are shown as orange boxes and the length of the alternative UTR (aUTR) is indicated below the gene structure. The length of the genome browser windows shown is indicated above in kilo bases (kb) between the two arrows

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