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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson’s, Alzheimer’s and ALS disease

Fig. 4

APA Regulation in F-PD compared to S-PD. a Bar chart to show the percentage of 3’UTR lengthening (red) and 3’UTR shortening (green) events in Familial-PD (F-PD) and Sporadic-PD (S-PD) compared to the two healthy controls (C1, C2) identified by DaPars analysis (PDUI > 0.25, Fisher’s exact Test p < 0.05). The total number of identified APA events are indicated by n beneath the chart. b A table showing the biological processes identified through GO analysis on the PANTHER platform for those genes that undergo significant APA either in S-PD an or F-PD. c Genome browser view of LONP1 for which 3’UTR shortening was observed in S-PD (blue track) but not F-PD (purple track) when compared to the control (green track). d Genome browser view of the 3’UTR lengthening observed in NELFA in F-PD (F-PD, purple track) compared to control (C, green track) but not in S-PD (S-PD, blue track). c & d, the proximal and distal poly(A) sites are shown as orange boxes and the length of the alternative UTR (aUTR) is indicated below the gene structure. The length of the genome browser windows shown is indicated above in kilo bases (kb) between the two arrows

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