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Table 1 Selection of novel genes involved in regulating cholesterol or triglyceride levels for in vitro functional studies

From: Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits

Gene Description Trait p-value (BioMe) β (BioMe) p-value (STARNET) β (STARNET) Tissue (STARNET)
CYP2C19 Cytochrome P450 Family 2 Subfamily C Member 19 TC 0.089 −32 0.033 0.10 LIV
PCK2 Phosphoenolpyruvate Carboxykinase 2, Mitochondrial TC 0.10 −23 0.00053 0.55 LIV
RNMTL1 RNA methyltransferase-like protein 1 TC 0.054 −36 0.016 0.60 LIV
SCRN2 Secernin 2 TC 0.089 −26 0.0026 0.39 LIV
UGT1A4 UDP Glucuronosyltransferase Family 1A4 TC 0.069 −13 2.1E-05 0.70 LIV
ABHD14B Abhydrolase Domain Containing 14B TG 0.027 −11 0.026 0.47 LIV
APOC3 Apolipoprotein C3 TG 0.0056 −56 0.0065 0.38 LIV
CES3 Carboxylesterase 3 TG 0.061 −40 0.00011 0.42 LIV
NMRAL1 NmrA-Like Family Domain Containing 1 TG 0.080 −28 0.045 0.28 LIV
SLC39A5 Solute Carrier Family 39 Member 5 TG 0.092 −70 0.0036 0.43 LIV
  1. Negative β in BioMe and positive β in STARNET indicate LoF and low gene expression are associated with decreased trait measurements
  2. LIV liver, TC total cholesterol, TG triglycerides